4,4-Dimethyl Effect (2). Syntheses, ^1H- and ^<13>C-Nuclear Magnetic Resonance Spectra, and the Conformations of 6α- and 6β-Substituted-1,1,10β-trimethyl-trans-decal-2-ones (8α- and 8β-Substituted-4,4,10β-trimethyl-trans-decal-3-ones), Models of 4,4-Dimet
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概要
- 論文の詳細を見る
A set of 6α- and 6β-(hydroxy, acetoxy, and p-bromobenzoyloxy)-1,1,10β-trimethyl-trans-decal-2-ones was synthesized in an unequivocal manner, and the ^1H-nuclear magnetic resonance (NMR) spectra, TH effect (ASIS shift on continuously changing the solvent from chloroform-d to benzene-d_6), and ^<13>C-NMR spectra of these compounds are discussed in relation to the conformations of ring A. In solution, ring A of the 6β-derivatives was shown to be more distorted (flattened) than that of 6α-derivatives. This was also true in the crystalline state as determined by X-ray analyses of their p-bromobenzoates. The TH effect was found to reflect sensitively small conformational changes in ring A.
- 社団法人日本薬学会の論文
- 1981-11-25
著者
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津田 喜典
金沢大学
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津田 喜典
Faculty of Pharmaceutical Sciences, Kanazawa University
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山下 武志
Faculty Of Pharmaceutical Sciences Kanazawa University
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津田 喜典
Faculty Of Pharmaceutical Sciences Kanazawa University
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吉本 公浩
Faculty of Pharmaceutical Sciences, Kanazawa University
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金田 幸
Faculty of Pharmaceutical Sciences, Kanazawa University
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吉本 公浩
金沢大学薬学部
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山下 武志
Faculty Of Pharmaceutical Sciences Kanazawa University:(present Address) Institute Of Pharmaceutical
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金田 幸
Faculty Of Pharmaceutical Sciences Kanazawa University:(present Address) Institute Of Pharmaceutical
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