Stereoselective Introduction of Oxygen Functionalities at the 11β-Position of Erythrinan Skeleton : Total Syntheses of (±)-Erythristemine and (+)-Erythrartine

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概要

• 論文の詳細を見る

• Oxidation of 8-oxoerythrinan and 8-oxo-1,7-cycloerythrinan derivatives with 2 mol eq of ceric ammonium nitrate in alcohols or acetic acid gave the corresponding 11β-alkoxy or acetoxy compounds in moderate yield. Thus, (±)-3,3,15,16-tetramethoxy-1,7-cycloerythrinan-2,8-dione and (+)-erysotramidine gave the corresoponding 11β-methoxy and 11β-acetoxy derivatives on oxidation in methanol and in acetic acid, respectively. Those compounds were respectively converted into (±)-erythristemine and (+)-erythrartine in several steps, thus achieving the total synthesis of these alkaloids.

• 社団法人日本薬学会の論文
• 1994-02-15

著者

• 津田 喜典

  金沢大学

• 津田 喜典

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 毛利 邦彦

  Showa College Of Pharmaceutical Sciences

• 鈴木 和美

  Showa College of Pharmaceutical Sciences

• 礒部 公明

  Showa College of Pharmaceutical Sciences

• 武田 尚子

  Showa College of Pharmaceutical Sciences

• 細井 信造

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 細井 深造

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 細井 深造

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 細井 信造

  金沢大薬

• 津田 喜典

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Suzuki Kazutoshi

  放射線医学総合研究所分子イメージング研究センター

• 津田 喜典

  金沢大薬

• Suzuki K

  Pharmaceutical Frontier Research Laboratories Japan Tobacco Inc.

• Suzuki Kenji

  Suntory Institute For Biomedical Research Wakayamadai

• Suzuki Kazutoshi

  Department Of Medical Imaging National Institute Of Radiological Sciences

• Suzuki Kazutoshi

  Clinical Neuroimaging Section Department Of Molecular Neuroimaging Molecular Imaging Center National

• Suzuki K

  Molecular Imaging Center National Institute Of Radiological Sciences

• Mohri K

  Showa College Of Pharmaceutical Sciences

• Isobe K

  Showa College Of Pharmaceutical Sciences

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