A NEW 1,2-CARBONYL TRANSPOSITION METHOD VIA PHENYLSELENENYLATION. HIGH YIELD TRANSFORMATION OF O-METHYLESTRONE TO O-METHYLISOESTRONE
スポンサーリンク
概要
- 論文の詳細を見る
Acidic phenylselenenylation of O-methylestrone with PhSeCl and BF_3.Et_2O gave an α-phenylselenenylketone and an α-chloro-α-phenylselenenylketone, both of which were converted to the same α, α-dimethoxyketone on treatment with mercury (II) perchlorate in methanol. Hydride reduction of this, dithiocarbonylation of the resulting product followed by acid hydrolysis, and treatment with tributyltin hydride gave O-methylisoestrone, the 1,2-carbonyl transposed product, in overall yield of 75%.
- 公益社団法人日本薬学会の論文
- 1985-04-25
著者
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津田 喜典
金沢大学
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津田 喜典
Faculty of Pharmaceutical Sciences, Kanazawa University
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細井 深造
Faculty of Pharmaceutical Sciences, Kanazawa University
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細井 深造
Faculty Of Pharmaceutical Sciences Kanazawa University
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津田 喜典
金沢大学薬学部
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津田 喜典
Faculty Of Pharmaceutical Sciences Kanazawa University
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