色彩計による生薬の品質評価(第2報) : 大黄の色彩と含有成分量
スポンサーリンク
概要
- 論文の詳細を見る
大黄の化学的な品質評価については,吸光度法による総結合型アソトラキノン類の定量,HPLC法あるいは近赤外分光分析計を用いたsennoside A, B(SA,SB)の定量,HPLCグラジエント法による多成分同時定量法など多くの報告がある.しかし,それらの定量法は,操作が煩雑であったり,また高価な機器を必要としている.われわれは色彩計を用いて,生薬の色彩と品質の関係について検討している. 今回,市場品大黄18検体の粉末や水抽出液の色を測定し,市販のデータ解析ソフトを利用して,原植物および含有成分anthrones (AR), anthraquinones (AQ), catechin (CA), gallic acid (GA),加水分解して得られるgallic acidの総量(Hy-GA)などの定量値との相関性を調査した.その結果,水抽出液を塩化第二鉄試液で発色させたときの色彩値とARおよびHy-GAとの間に高い相関性が得られ,色彩計を用いて大黄の成分化学的な品質評価が容易に行いうることを明らかにしたので報告する.
- 日本生薬学会の論文
- 1992-06-20
著者
-
津田 喜典
金沢大学
-
津田 喜典
金沢大学薬学部
-
御影 雅幸
金沢大学薬学部
-
近藤 誠三
Research Institute Of Kotarhoh Pharmaceutical Co. Ltd.
-
近藤 誠三
小太郎漢方製薬研究所
-
近藤 誠三
小太郎漢方製薬株式会社
-
高野 昭人
金沢大学薬学部
関連論文
- 糖類水酸基の一選択的修飾と変換 : スズ化合物による水酸基の選択的活性化
- Studies on Crude Drugs Effective on Visceral Larva Migrans. IV. : Isolation and Identification of Larvicidal Principles in Pepper
- Studies on Crude Drugs Effective on Visceral Larva Migrans. III. : The Bursting Activity of Tannins on Dog Roundworm Larva
- Studies on Crude Drugs Effective on Visceral Larva Migrans. II. : Larvicidal Principles in Kaempferiae Rhizoma
- Studies on Crude Drugs Effective on Visceral Larva Migrans. I. Identification of Larvicidal Principles in Betel Nuts(Pharmacognosy,Chemical)
- A Convenient Synthesis of Tertiary Amines by Alkylation of Secondary Amines with Alkyl Halides in the Presence of Potassium Hydride and Triethylamine
- Stereoselective Introduction of Oxygen Functionalities at the 11β-Position of Erythrinan Skeleton : Total Syntheses of (±)-Erythristemine and (+)-Erythrartine
- Anthelmintic Effect of the Embelia ribes Decoction and Embelin Derivatives on Trichuris muris in Mice
- Trichuris muris : The Anthelmintic Effect of Mebendazole in Mice is Dependent upon the Pre-treatment with Steroids
- Mobility Inhibition and Nematocidal Activity of Asarone and Related Phenylpropanoids on Second-Stage Larvae of Toxocara canis
- A Tetrazorium Dye (MTT) Assay for Testing Larval Viability Using Second-Stage Larvae of Toxocara canis
- Nematocidal Activity of Turmeric : Synergistic Action of Curcuminoids
- Nematocidal Principles in "Oakmoss Absolute" and Nematocidal Activity of 2,4-Dihydroxybenzoates
- Studies on Crude Drugs Effective on Visceral Larva Migrans. V. : The Larvicidal Principle in Mace (Aril of Myristica fragrans)
- Chiral Synthesis of Erythrina Alkaloids. (2). Synthesis of enantio-Type Erythrinan Alkaloids Utilizing Asymmetric Acylation and Kinetic Resolution of Diastereomers
- CHIRAL SYNTHESIS OF ENANTIO-TYPE ERYTHRINAN ALKALOIDS UTILIZING ASYMMETRIC ACYLATION AND KINETIC RESOLUTION OF DIASTEREOMERS
- 4,4-Dimethyl Effect (2). Syntheses, ^1H- and ^C-Nuclear Magnetic Resonance Spectra, and the Conformations of 6α- and 6β-Substituted-1,1,10β-trimethyl-trans-decal-2-ones (8α- and 8β-Substituted-4,4,10β-trimethyl-trans-decal-3-ones), Models of 4,4-Dimet
- Barbaloin Stimulates Growth of Eubacterium sp. Strain BAR, a Barbaloin-Metabolizing Bacterium from Human Feces
- 4,4-Dimethyl Effect. (3). The Ring A Conformation of 4,4-Dimethyl-Δ^7-3-keto Steroids and 4,4,8-β-Trimethyl-3-keto Steroids (3-Keto-triterpenoids). The Crystal Structure of Serratenedione
- Synthesis of Endomorphin-2Analogues Containing Piperidinecarboxylic Acid (Pip) and 2-Azetidinecarboxylic Acid (Aze)
- Synthesis and Biological Activity of Endomorphin-2 Analogues Containing Pro Mimics
- Synthesis and Binding Activities of Endomorphin Analogs Containing 1-Aminocyclopropane-1-carboxylic Acid
- 90(P04) β-エリスロイジンの合成研究(ポスター発表の部)
- ASYMMETRIC [2+2] PHOTOCYCLOADDITION REACTION OF A CHIRAL DIOXOPYRROLINE TO 2-(TRIMETHYLSILYLOXY)BUTADIENE : CHIRAL SYNTHESIS OF ERYTHRINA ALKALOIDS
- A Stable Monosubstituted Isoindole Derivative : The Crystal Structure of 1-(1,2,3-1H-Benzotriazol-1-yl)-2-(4-methylphenyl)-2H-isoindole
- REARRANGEMENT OF 2,3-DIOXO-1,4-OXAZINES TO 4,5-DIOXOOXAZOLES IN THE REACTION WITH DIMETHYLSULFOXONIUM METHYLIDE
- Chiral Synthesis of Erythrina Alkaloids. I. Total Synthesis of (+)-Erysotrine via Asymmetric Diels-Alder Reaction under High Pressure
- Synthesis of Highly Deydrogenated Oxoerythrinan Alkaloids, Erytharbine and Crystamidine
- Dioxypyrrolines. LV. Stereochemical Pathway of [2+2]Photocycloaddition Reaction of 4,5-Diethoxycarbonyl-1H-pyrrole-2,3-dione to Cycloalkadienes and Cycloalkenes
- Chemistry of Oxo-Sugars. (2). Regio- and Stereo-Selective Synthesis of Methyl D-Hexopyranosiduloses and Identification of Their Forms Existing in Solutions
- Dioxopyrroline. LIV. Steretchemical Pathway of[2+2]Photocycloaddition Reaction of 4,5-Diethoxycarbonyl-1H-pyrrole-2,3-dione to Acyclic Olefins
- Dioxopyrrolines. LIII.Stereochemical Pathway of [2+2] Photocycloaddition Reaction of 4-Ethoxycarbonyl-5-phenyl-1H-pyrrole-2,3-dione to Cyclic Enol Trimethylsilyl Ethers
- 茯苓の研究-1-菌核の産出状況および形態
- 色彩計による生薬の品質評価-1-粉末生薬の測定条件と人参類生薬の品質評価
- Reaction of Phenylselenenyl Chloride with Δ^2-Erythrinans in Methanol : Conformational Fluctuation and Stereochemical Pathway
- Hydride Reduction of Erythrinan-7,8-diones and 7-O-Methanesulfonyl-8-oxo-erythrinans
- Synthesis of Erythrina and Related Alkaloids.XXIV. Total Synthesis of Erysotrine from 1,7-Cycloerythrinan Derivatives by the Use of a New 1,2-Carbonyl Transposition Method
- Photo-Cycloaddition of 3-Methoxycyclohexenone and 3-Aminocyclohexenone to Ethoxyethylene : Stereochemistry of the Cycloadducts
- Regioselective Syntheses of Mono-O-acylglucoses
- SYNTHESIS OF SOME DEOXY, UNSATURATED, AND DIDEOXY SUGARS VIA REGIOSELECTIVE THIOACYLATION OF GLYCOPYRANOSIDES BY THE DIBUTYLTIN OXIDE METHOD
- Regioselective Monotosylation of Non-protected and Partially Protected Glycosides by the Dibutyltin Oxide Method
- 4,4-Dimethyl Effect. (4). The Conformation of α-Onoceradienedione in the Crystalline State
- Regioselective Introduction of a Methoxy Group at the Benzylic Position of Isochromane Derivatives by Cerium(IV) Oxidation in Methanol
- SYNTHESIS OF COCCULOLIDINE SKELETON, A NON-AROMATIC NOR-ERYTHRINAN ALKALOID(Communications to the Editor)
- REGIOSELECTIVE INTRODUCTION OF p-COUMAROYL GROUP TO α-L-ARABINO-PYRANOSIDES. TOTAL SYNTHESES OF INUNDOSIDE-G AND INUNDOSIDE-D_1
- Regioselective Monoacylation of Some Glycopyranosides via Cyclic Tin Intermediates
- 26 ホモエリスリナアルカロイド,(±)schelhammericine,(±)3-epischelhammericineの全合成
- TOTAL SYNTHESIS OF THE HOMOERYTHRINAN ALKALOIDS, SCHELHAMMERICINE AND 3-EPISCHELHAMMERICINE
- Conversion of Thiocarbonyl into Carbonyl Group by O-S Exchange Reaction with Dibutyltin Oxide or Bistributyltin Oxide
- Total Synthesis of Hydroxyhopanone
- Synthesis of Malabaricones, Diarylnonanoids Occurring in Myristicaceous Plants
- A NEW 1,2-CARBONYL TRANSPOSITION METHOD VIA PHENYLSELENENYLATION. HIGH YIELD TRANSFORMATION OF O-METHYLESTRONE TO O-METHYLISOESTRONE
- Infrared Spectra of Conjugated Amides : Reassignment of the C=O and C=C Absorptions
- Differential Receptor Recognition by Dmt-Containing Enkephalin Dimers Cross-Linked by Phenylenediamines
- Application of liquid chromatography-tandem mass spectrometry for the determination of opioidmimetics in the brain dialysates from rats treated with opioidmimetics intraperitoneally
- Synthesis and Nematocidal Activity of Hydroxystilbenes
- Enantioselective Synthesis of a Phenylalanine Library Containing Alkyl Groups on the Aromatic Moiety : Confirmation of Stereostructure by X-Ray Analysis
- The Antiproliferative Activities of Somatostatin Analogs on Various Tumor Cells
- Roles of Each Component of μ-Opioid Ligands Containing Dmt-Pyrazinones
- Studies on the Mechanism of 1,2-Dihydropyrazin-2-one Ring Formation from Dipeptidyl Chloromethyl Ketone and Its Chemical Properties : Immediate Deamination during Catalytic Hydrogenation
- Synthesis and Bioactivity of Novel Type Pyrazinone Ring-Containing μ-Opioid Ligands
- Generation of a Selective Agonist for Mu-Opioid Receptors by the Dimerization of 2', 6'-Dimethyl-L-Tyrosine through Pyrazinone
- 68 二,三の天然アシル化糖およびアシル化配糖体の合成 : 糖類に対する位置選択的アシル基の導入
- スピロ型構造を持ったアルカロイド群の全合成
- 日本薬学会奨励賞受賞森裕二氏の業績
- 白樺6大学合同セミナーなど(研究者の能力を高めるために実行している教育)
- ヒガンバナ科アルカロイドの全合成
- "薬とは何か"の化学(薬品化学で何を教えるか)
- 日本薬学会学術賞紹介-2 : 藤田栄一氏の業績
- 医薬品の開発と天然物化学(薬学領域において天然物化学研究に託される役割り)
- I-C-9 腸内細菌による和漢薬成分の代謝(第 22 報) : Eubacterium sp. BAR における Barbaloin 代謝酵素の誘導
- New Method for Isomerization of (Z)-Stilbenes into the (E)-Isomers Catalyzed by Diaryl Disulfide
- CHEMISTRY OF OXO-SUGARS (1). REARRANGEMENT OF 2-OXOGLYCOSIDES IN PYRIDINE : EVIDENCE OF INTRAMOLECULAR HYDRIDE SHIFT
- Isolation and Structure Elucidation of Gymnemic Acids, Antisweet Principles of Gymnema sylvestre
- TRIALKYLTIN RADICAL USED TO CATALYZE THE O,S-REARRANGEMENT OF CYCLIC THIONOCARBONATES. A NEW ENTRY TO THIO-SUGARS(Communication to the Editor)
- 天然由来殺寄生虫物質
- Lithium Aluminum Hydride Reduction of Glycopyranoside-Monosulfonates : Formation of Branched Furanosides
- TWO NEW GYMNEMIC ACID CONGENERS CONTAINING A HEXULOPYRANOSIDE MOIETY
- Z-E Isomerization of β-Methoxychalcones : Preferred Existence of E-Isomers in Naturally Occurring β-Methoxychalcones
- Regio- and Stereo-Selective Transformation of Glycosides to Amino-glycosides : Practical Synthesis of Amino-sugars, 4-Amino-4-deoxy-D-galactose, 4-Amino-4-deoxy-L-arabinose, 3-Amino-3-deoxy-D-allose, 3-Amino-3-deoxy-D-glucose, 3-Amino-3-deoxy-D-ribose, 3-
- Regioselective Mono-oxidation of Non-protected Carbohydrates by Brominolysis of the Tin Intermediates
- Selective Deoxygenation via Regioselective Thioacylation of Non-protected Glycopyranosides by the Dibutyltin Oxide Method(Organic,Chemical)
- Hexahydro-dibenz[d, f]azecines : Existence of Two Conformational Isomers of the 6-Oxo Derivatives in Solution
- Regioselective Monoalkylation of Non-protected Glycopyranosides by the Dibutyltin Oxide Method
- The Alkaloidal Constituents of Goda-Manel (Crinum zeylanicum L.), a Sri Lankan Folk Medicine
- A Highly Stereoselective Synthesis of rel[1R, 3R, 7R, 9S]9-Acetoxy-8,8-dimethyltricyclo[5.4.0.0^]undecan-4-one, a Versatile Intermediate to Terpenoids. Synthesis of α-Onocerin
- ^C-Nuclear Magnetic Resonance (NMR) Spectra of O-Acylglucoses. Additivity of Shift Parameters and Its Application to Structure Elucidations
- Syntheses and ^1H- and ^C-Nuclear Magnetic Resonance Spectra of All Positional Isomers of Methyl Mono-O-tetradecanoyl-a- and β-D-Glucopyranosides
- REGIOSELECTIVE MONO-OXIDATION OF NON-PROTECTED GLYCOSIDES BY THE BIS-TRIBUTYLTIN OXIDE-BROMINE METHOD
- 4,4-Dimethyl Effect. (6). The Ring A Conformation of 4,4-Dimethyl-3-keto Steroids and Triterpenoid-3-ketones : Predicted and Observed Geometries and Their Chiroptical Properties
- 4,4-Dimethyl Effect. (5). The Conformation of 8αH, 14βH-Onocerane-3,21-dione (Onoceranedione-I) in the Crystalline State
- アシル化糖の位置選択的合成とその転位 : 糖類水酸基の位置選択的修飾
- On the Possibility of Direct O-1β→ -6 Acyl Migration in 1-O-Acyl-β-D-glucose Derivatives
- General Path of O-Acyl Migration in D-Glucose Derivatives : Acyl Migration of Methyl Mono-O-myristoyl-α- and β-D-Glucopyranosides and Mono-O-myristoyl-D-glucopyranoses
- REGIOSELECTIVE OXIDATION OF A β-L-ARABINOPYRANOSIDE VIA CYCLIC TIN INTERMEDIATE. FACILE SYNTHESIS OF 4-AMINO-4-DEOXY-L-ARABINOSE, AN AMINO-SUGAR FOUND IN LIPOPOLYSACCHARIDES OF SOME SALMONELLA R MUTANT STRAINS
- Practical Syntheses of [R]- and [S]-1-Alkylamino-3-aryloxy-2-porpanols from a Single Carbohydrate Precursor
- Highly Stereoselective Grignard Reaction of an Aldopyranose : A Simple synthesis of 6-Deoxy-D-idose from D-Xylose
- 色彩計による生薬の品質評価(第2報) : 大黄の色彩と含有成分量
- ネパール産カギカズラ属植物Uncaria scandensの形態とアルカロイド成分
- 色彩計による生薬の品質評価(第1報) : 粉末生薬の測定条件と人参類生薬の品質評価