Highly Stereoselective Grignard Reaction of an Aldopyranose : A Simple synthesis of 6-Deoxy-D-idose from D-Xylose
スポンサーリンク
概要
- 論文の詳細を見る
Grignard reaction of 2,3,4-tri-O-benzyl-D-xylopyranose yielded a single product with very high stereoselectivity. A threo relationship of the newly created chiral center with respect to C_2 was established by converting the product into the δ-lactone of D-ido configuration, then to the unsaturated lactone of threo configuration. The result made possible a stereoselective synthesis of 6-deoxy-D-idose from D-xylose in a small number of steps. Models accounting for the high stereoselectivity in the Grignard reaction of aldoses are discussed.
- 公益社団法人日本薬学会の論文
- 1980-11-25
著者
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津田 喜典
金沢大学
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布沢 哲二
Fuji Chemical Industry Co. Ltd.,
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津田 喜典
Faculty Of Pharmaceutical Sciences Kanazawa University
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吉本 公浩
Faculty of Pharmaceutical Sciences, Kanazawa University
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吉本 公浩
金沢大学薬学部
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布沢 哲二
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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布沢 哲二
Fuji Chemical Industry Co. Ltd.
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