Preparation of Some Acetylated, Reduced and Oxidized Derivatives of 2,4-Diaminotoluene and 2,6-Dinitrotoluene

概要

論文の詳細を見る
4-Acetylamino-2-hydroxylaminotoluene (4AA2HAT) and 2-hydroxylamino-6-nitrotoluene (2HA6NT) were prepared from 4-acetylamino-2-nitrotoluene (4AA2NT) and 2,6-dinitrotoluene (2,6-DNT), respectively, by reduction with zinc dust and NH_4Cl. 2,6-Dinitrobenzylalcohol (2,6-DNB) and 2,6-dinitrobenzoic acid (2,6-DNBA) were prepared from 2,6-dinitrobenzaldehyde (2,6-DNBA1) by reduction with NaBH_4 and by oxidation with KMnO_4,respectively. 2-Acetylamino-4-aminobenzoic acid (2AA4ABA) was prepared from 4-nitroanthranilic acid (4NAA) by acetylation followed by reduction with NaBH_4 and Pd-C. 2,4-Diacetylaminobenzoic acid (2,4-DAABA) was prepared from 4NAA by reduction with NaBH_4 and Pd-C followed by acetylation. 4-Acetylamino-2-aminobenzoic acid (4AA2ABA) was prepared from 4NAA by reduction and acetylation followed by chelation with Cu(AcO)_2.
公益社団法人日本薬学会の論文
1986-11-25