Influence of Poisonous Metals on the Bone Metabolism. II. The Effect of Cadmium on the Metabolism of Chondroitin Sulfate in Embryonic Chicken Limb Bone

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The effect of cadmium on chondroitin sulfate synthesizing and releasing activities in embryonic chicken limb bone was studied. At the concentration more than 20 ppm CdCl_2,cadmium enhanced the release of chondroitin sulfate into the medium. However, at the concentration of 5 to 10 ppm CdCl_2,cadmium inhibited the incorporation of ^<35>S into chondroitin sulfate. These findings suggest that the primary action of cadmium to the chondroitin sulfate metabolism is the inhibition of the synthesis. p-Nitrophenyl-β-D-xyloside did not reverse the inhibition of chondroitin sulfate synthesis brought about by cadmium. Furthermore, cadmium inhibited the incorporation of [^3H]-acetate into UDP-N-acetyl hexosamine. From these results, we suppose that cadmium inhibits mainly the synthesis of nucleotides, even though the inhibition of cadmium to core protein synthesis and chain elongation may be extensively excluded.
公益社団法人日本薬学会の論文
1978-02-28