Dietary Manipulation by Perilla Oil and Fish Oil of Hepatic Lipids and Its Influence on Peroxisomal β-Oxidation and Serum Lipids in Rat and Mouse
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概要
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Rats and mice were fed a diet, prepared with soybean oil (SO), perilla oil (PO) or fish oil (FO), for 4 weeks. Compared with the groups of SO-feeding, FO-feeding increased content of eicosapentaenoic acid (20 : 5 n-3), docosapentaenoic acid (22 : 5 n-3) and docosahexaenoic acid (22 : 6 n-3) and PO-feeding elevated the content of α-linolenic acid (18 : 3 n-3), 20 : 5 n-3 and 22 : 5 n-3 of hepatic lipids of both rats and mice. FO-feeding increased the activity of peroxisomal β-oxidation in the livers of both rats and mice. The activities of peroxisomal β-oxidation in rats and mice that were fed FO diet at a high fat (40% of energy) concentration corresponded to 20% and 30%, respectively, of the maximum activities induced by peroxisome proliferators (4-chlorophenoxyisobutyric acid or perfluorooctanoic acid). To a lesser extent, PO-feeding elevated this activity too. There were significant correlations between peroxisomal β-oxidation activity and the content of either 20 : 5 n-3,22 : 5 n-3 or 22 : 6 n-3 in hepatic lipids. FO-feeding decreased effectively serum level of cholesterol of both rats and mice. The reduction in serum cholesterol by feeding PO was less pronounced than that observed with FO-feeding. A high correlation was found between 22 : 6 n-3 content in hepatic lipids and serum concentration of cholesterol. Although FO-feeding lowered the level of circulating triacylglycerol, PO-feeding produced no change. No substantial correlation was observed between the hepatic content of n-3 fatty acid and the concentration of serum triacylglycerol. These results suggest that manipulation of the acyl composition of hepatic lipids by polyunsaturated fatty acids of the n-3 series lead to alterations in peroxisomal β-oxidation activity and circulating a cholesterol level. The physiological significance of n-3 fatty acid-mediated enhancement of the activity of peroxisomal β-oxidation was discussed.
- 公益社団法人日本薬学会の論文
- 1993-12-15
著者
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川島 洋一
富山医科薬科大学 薬
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狐塚 寛
Faculty of Pharmaceutical Sciences, Toyama University
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孤塚 寛
Section Of Toxicology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical Universit
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狐塚 寛
富山医科薬科大学薬学部
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川嶋 洋一
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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狐塚 寛
Department Of Toxicology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical Univer
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Kozuka H
Department Of Toxicology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical Univer
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川嶋 洋一
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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