Stimulation of Cultured Vascular Smooth Muscle Cell Proliferation by Thrombospondin Is Potentiated by Zinc

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概要

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• The interaction of zinc sulfate with thrombospondin (TSP) derived from bovine platelets, on the proliferation of bovine aortic smooth muscle cells was investigated using cell culture. Zinc alone has no effect but potentiates the stimulatory effect of TSP on the incorporation of [^3H] thymidine into the acid-insoluble cell fraction. Other heavy metals including copper, lead, manganese and nickel did not exhibit a similar effect. In bovine aortic endothelial cells, [^3H] thymidine incorporation was stimulated by zinc alone and suppressed by TSP alone ; the stimulation by zinc was significantly reduced by TSP. In human fibroblastic IMR-90 cells, [^3H] thymidine incorporation was stimulated by either zinc or TSP ; a simultaneous treatment with zinc and TSP showed an additive effect. The present data suggest that zinc may be a unique heavy metal that potentiates the proliferation of vascular smooth muscle cells stimulated by TSP ; in addition, such an interaction was observed selectively in this cell type. Since a large amount of TSP is released from α-granules of aggregated platelets, zinc may augment TSP activity which is involved in the physiology of vascular tissues.

• 社団法人日本薬学会の論文
• 1995-09-15

著者

• 鍛冶 利幸

  Department of Environmental Science, Faculty of Pharmaceutical Sciences, Hokuriku University

• 山本 千夏

  Department of Environmental Science, Faculty of Pharmaceutical Sciences, Hokuriku University

• 坂元 倫子

  Department of Environmental Science, Faculty of Pharmaceutical Sciences, Hokuriku University

• 鍛冶 利幸

  北陸大学 薬学部 境健康学教室

• 鍛冶 利幸

  北陸大学 薬学部

• 坂元 倫子

  北陸大薬環境衛生

• 孤塚 寛

  Section Of Toxicology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical Universit

• 藤原 泰之

  北陸大学 薬学部

• 鍜冶 利幸

  北陸大学 薬学部

• 坂元 倫子

  北陸大学 薬 環境科

• 坂元 倫子

  北陸大・薬・環境科学

• 坂本 倫子

  北陸大学 薬 環境衛

• 鍜治 利幸

  北陸大・薬

• 鍛治 利幸

  北陸大学薬学部環境健康学

• Yamamoto Chika

  Department Of Environmental Science Faculty Of Pharmaceutical Sciences Hokuriku University

• 藤原 泰之

  Department of Environmental Science, Faculty of Pharmaceutical Sciences, Hokuriku University

• 狐塚 寛

  Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical Univ

• 坂元 倫子

  北陸大学薬学部環境衛生学教室

• Sakamoto M

  Department Of Environmental Science Faculty Of Pharmaceutical Sciences Hokuriku University

• 狐塚 寛

  Department Of Toxicology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical Univer

• Kaji T

  北陸大学薬学部:北陸大学学術フロンティア研究組織

• Kozuka H

  Department Of Toxicology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical Univer

• Yamamoto C

  北陸大学薬学部:北陸大学学術フロンティア研究組織

• 坂元 倫子

  Department Of Environmental Science Faculty Of Pharmaceutical Sciences Hokuriku University

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