Analysis of Chondroitin/Dermatan Sulfate Microstructure in Cultured Vascular Smooth Muscle Cells after Exposure to Lead and Cadmium
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概要
- 論文の詳細を見る
Chondroitin/dermatan sulfate chains consist of a repeating disaccharide unit of glucuronic acid (GlcA)/ iduronic acid (IdoA) and N-acetylgalactosamine (GalNAc) with or without O-sulfation at the C-4 and C-6 position of GalNAc and at the C-2 position of IdoA. Lead and cadmium influence the synthesis of chondroitin/dermatan sulfate proteoglycan core proteins in vascular smooth muscle cells when the cell density is high and low, respectively. However, it has been unclear whether the metals influence the synthesis of chondroitin/dermatan sulfate chains. In the present study, it was shown that lead inhibits the formation of GlcAβ1-3GalNAc, GlcAβ1-3GalNAc(4S) and GlcAβ1-3GalNAc(6S) in dense cells, whereas cadmium inhibits the formation of GlcAβ1-3GalNAc(4S) and GlcAβ1-3GalNAc(6S) but increases that of IdoAβ1-3GalNAc(4S) in the sparse cells. The present data support the hypothesis that lead and cadmium may influence the composition of chondroitin/dermatan sulfate in atherosclerotic vascular wall depending on the density of vascular smooth muscle cells.
- 社団法人日本薬学会の論文
- 2003-12-01
著者
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Fujiwara Yasuyuki
北陸大学 薬学部環境健康学
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Fujiwara Yasuyuki
Lab. Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin Univ.
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Kaji T
Organization For Frontier Research In Preventive Pharmaceutical Sciences Hokuriku University
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Kaji Toshiyuki
Organization For Frontier Res. In Preventive Pharmaceutical Sciences Hokuriku Univ.
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Kaji Toshiyuki
Department Of Environmental Science Faculty Of Pharmaceutical Sciences Hokuriku University
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Yamamoto Chika
Department of Environmental Health, Faculty of Pharmaceutical Sciences, Hokuriku University
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Fujiwara Yasuyuki
Department of Environmental Health, Faculty of Pharmaceutical Sciences, Hokuriku University
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Plass Annna
Department of Internal Medicine, College of Medicine, University of South Florida
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Plaas A
Univ. South Florida Fl Usa
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Kaji Toshiyuki
Department Of Environmental Sciences Faculty Of Pharmaceutical Sciences Hokuriku University
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Kaji Toshiyuki
Department Of Environmental Health Faculty Of Pharmaceutical Sciences:organization For Frontier Rese
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Kaji Toshiyuki
Department Of Environmental Health Faculty Of Pharmaceutical Sciences Hokuriku University
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Yamamoto C
Organization For Frontier Research In Preventive Pharmaceutical Sciences Hokuriku University
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Yamamoto Chika
Department Of Environmental Health Faculty Of Pharmaceutical Sciences Hokuriku University
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Fujiwara Yasuyuki
Dep. Of Environmental Health Fac. Of Pharmaceutical Sciences Hokuriku Univ.
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Fujiwara Yasuyuki
Department Of Cardiovascular Surgery Seijunkai Johoku Hospital
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Plaas Anna
Department Of Internal Medicine College Of Medicine University Of South Florida
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Plass Annna
Department Of Internal Medicine College Of Medicine University Of South Florida
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Kaji T
北陸大学薬学部:北陸大学学術フロンティア研究組織
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Yamamoto Chika
Organization Of Frontier Research For Preventive Pharmaceutical Science Hokuriku University:departme
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