An Organobismuth Compound that Exhibits Selective Cytotoxicity to Vascular Endothelial Cells in Vitro
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概要
- 論文の詳細を見る
Selective cytotoxicity of chemical compounds to vascular endothelial cells is often beneficial for clinical applications including antivascular cancer therapy. In this study, the cytotoxicity of 35 organic compounds containing bismuth or antimony was evaluated based on the leakage of lactate dehydrogenase and morphologic observations in cultured bovine aortic endothelial cells and other cell types. The results indicate that only tris[2-(N, N-dimethylaminomethyl)phenyl]-bismuthane (TDPBi) had potent cytotoxicity to bovine aortic endothelial cells but not to bovine aortic smooth muscle cells and porcine kidney epithelial LLC-PK_1 cells; the compound exhibited moderate cytotoxicity to human fetal lung fibroblastic IMR-90 cells. Neither inorganic bismuth nor tris[2-(N, N-dimethylaminomethyl)phenyl]stibane, in which antimony substitutes for bismuth with the same organic structure as TDPBi, exhibited cytotoxicity to vascular endothelial cells, suggesting that the entire structure of TDPBi is required for selective cytotoxicity. The present data revealed that TDPBi has selective cytotoxicity to vascular endothelial cells, which may be applicable in antivascular cancer therapy.
- 公益社団法人日本薬学会の論文
- 2005-06-01
著者
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FUJIWARA Yasuyuki
Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
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Fujiwara Yasuyuki
北陸大学 薬学部環境健康学
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Fujiwara Yasuyuki
Lab. Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin Univ.
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Kaji T
Organization For Frontier Research In Preventive Pharmaceutical Sciences Hokuriku University
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Kaji Toshiyuki
Organization For Frontier Res. In Preventive Pharmaceutical Sciences Hokuriku Univ.
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Kaji Toshiyuki
Department Of Environmental Science Faculty Of Pharmaceutical Sciences Hokuriku University
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Fujiwara Yasuyuki
Department of Environmental Health, Faculty of Pharmaceutical Sciences, Hokuriku University
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Kaji Toshiyuki
Department Of Environmental Sciences Faculty Of Pharmaceutical Sciences Hokuriku University
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Kaji Toshiyuki
Department Of Environmental Health Faculty Of Pharmaceutical Sciences:organization For Frontier Rese
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Kaji Toshiyuki
Department Of Environmental Health Faculty Of Pharmaceutical Sciences Hokuriku University
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Fujiwara Yasuyuki
Dep. Of Environmental Health Fac. Of Pharmaceutical Sciences Hokuriku Univ.
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Fujiwara Yasuyuki
Department Of Environmental Health Faculty Of Pharmaceutical Sciences
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Fujiwara Yasuyuki
Department Of Cardiovascular Surgery Seijunkai Johoku Hospital
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Mitani Makoto
Department of Environmental Health, Faculty of Pharmaceutical Sciences, Hokuriku University
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Yasuike Shuji
Department of Organic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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Kurita Jyoji
Department of Organic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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Kaji T
北陸大学薬学部:北陸大学学術フロンティア研究組織
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Mitani Makoto
Department Of Environmental Health Faculty Of Pharmaceutical Sciences Hokuriku University:department
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Yasuike Shuji
Department Of Organic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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