Selective Promotion of Plasminogen Activator Inhibitor-1 Secretion by Activation of Proteinase-Activated Receptor-1 in Cultured Human Brain Microvascular Pericytes : Comparison with Endothelial Cells(Biochemistry/Molecular Biology)
スポンサーリンク
概要
- 論文の詳細を見る
Microvessels are composed of endothelial cells that cover the luminal surface and pericytes that wrap around and along endothelial cells. In the present study, we investigated the regulation of fibrinolysis in cultured human brain microvascular pericytes and endothelial cells after exposure to thrombin. It was found that the regulation in pericytes is different from that in endothelial cells. Specifically, thrombin increases the secretion of fibrinolytic proteins (tissue- and urokinase-type plasminogen activators and plasminogen activator inhibitor-1), resulting in an enhancement of plasminogen activator activity in endothelial cells, whereas the proteinase increases the secretion of only plasminogen activator inhibitor-1 by activation of proteinase-activated receptor-1 and induces suppression of plasminogen activator activity in pericytes. The present data suggest that thrombin regulation of fibrinolytic activity in endothelial cells and pericytes may be involved in the removal of intravascular thrombi and the maintenance of hemostasis, respectively, in human brain microvessels.
- 社団法人日本薬学会の論文
- 2005-02-01
著者
-
FUJIWARA Yasuyuki
Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
-
Fujiwara Yasuyuki
北陸大学 薬学部環境健康学
-
Fujiwara Yasuyuki
Lab. Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin Univ.
-
Kaji T
Organization For Frontier Research In Preventive Pharmaceutical Sciences Hokuriku University
-
Kaji Toshiyuki
Organization For Frontier Res. In Preventive Pharmaceutical Sciences Hokuriku Univ.
-
Kaji Toshiyuki
Department Of Environmental Science Faculty Of Pharmaceutical Sciences Hokuriku University
-
Yamamoto Chika
Department of Environmental Health, Faculty of Pharmaceutical Sciences, Hokuriku University
-
Fujiwara Yasuyuki
Department of Environmental Health, Faculty of Pharmaceutical Sciences, Hokuriku University
-
SUGATO Minako
Department of Environmental Health, Faculty of Pharmaceutical Sciences, Hokuriku University
-
Kaji Toshiyuki
Department Of Environmental Sciences Faculty Of Pharmaceutical Sciences Hokuriku University
-
Kaji Toshiyuki
Department Of Environmental Health Faculty Of Pharmaceutical Sciences:organization For Frontier Rese
-
Kaji Toshiyuki
Department Of Environmental Health Faculty Of Pharmaceutical Sciences Hokuriku University
-
Yamamoto C
Organization For Frontier Research In Preventive Pharmaceutical Sciences Hokuriku University
-
Yamamoto Chika
Department Of Environmental Health Faculty Of Pharmaceutical Sciences Hokuriku University
-
Sakamoto Michiko
Laboratory Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin University
-
Fujiwara Yasuyuki
Dep. Of Environmental Health Fac. Of Pharmaceutical Sciences Hokuriku Univ.
-
Fujiwara Yasuyuki
Department Of Environmental Health Faculty Of Pharmaceutical Sciences
-
Fujiwara Yasuyuki
Department Of Cardiovascular Surgery Seijunkai Johoku Hospital
-
Satoh Masahiko
Lab. Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin Univ.
-
Satoh Masahiko
Department Of Hygienics Gifu Pharmaceutical University
-
Kaji T
北陸大学薬学部:北陸大学学術フロンティア研究組織
-
Yamamoto Chika
Organization Of Frontier Research For Preventive Pharmaceutical Science Hokuriku University:departme
関連論文
- Microarray analysis of the liver in metallothionein-III null mice treated with cadmium
- Resistance of human brain microvascular endothelial cells in culture to methylmercury : cell-density-dependent defense mechanisms
- Microarray analysis of the liver in metallothionein-III null mice treated with cadmium
- Involvement of metallothionein (MT) as a biological protective factor against carcinogenesis induced by benzo[a]pyrene (B[a]P)
- Resistance of metallothionein-III null mice to cadmium-induced acute hepatotoxicity
- Protective role of metallothionein in benzo[a]pyrene-induced DNA damage
- Effect of metallothionein on cadmium accumulation in fetus(Metal toxicity, Proceedings of the 32nd Annual Meeting)
- Protective effect of metallothionein on benzo[a]pyrene-caused DNA damage(Proceedings of the 32nd Annual Meeting)
- DNA microarray analysis of transcriptional responses of mouse spinal cords to physical exercise(Toxicogenomics/proteomics Report)
- Preventive Effect of Preinduction of Metallothionein on Mutagenicity Caused by Benzo[a]pyrene
- Suppression of fibroblast growth factor-2 expression : Possible mechanism underlying methylmercury-induced inhibition of the repair of wounded monolayers of cultured human brain microvascular endothelial cells
- Arsenite but not arsenate inhibits general proteoglycan synthesis in cultured arterial smooth muscle cells
- Homocysteine Inhibits Proteoglycan Synthesis in Cultured Bovine Aortic Smooth Muscle Cells
- Methylmercury Retards the Repair of Wounded Monolayer of Human Brain Microvascular Endothelial Cells by Inhibiting Their Proliferation without Nonspecific Cell Damage
- The Biological Effects of Depolymerized Sodium Spirulan and Sulfated Colominic Acid on Vascular Cells are Beneficial in Preventing Atherosclerosis
- Proteoglycans Predominantly Synthesized by Human Brain Microvascular Endothelial Cells in Culture are Perlecan and Biglycan
- Selective Promotion of Plasminogen Activator Inhibitor-1 Secretion by Activation of Proteinase-Activated Receptor-1 in Cultured Human Brain Microvascular Pericytes : Comparison with Endothelial Cells(Biochemistry/Molecular Biology)
- Proteoglycans Released from Cultured Bovine Aortic Endothelial Cell Layers by Sodium Spirulan Are Both Perlecan and Biglycan(Biochemistry/Molecular Biology)
- Stimulation of Proteoglycan Release from Cultured Vascular Endothelial Cell Layers by Sodium Spirulan
- Characterization of Chondroitin/Dermatan Sulfate Proteoglycans Synthesized by Bovine Retinal Pericytes in Culture(Highlighted paper selected by Editor-in-chief)(Biochemistry/Molecular Biology)
- Analysis of Chondroitin/Dermatan Sulfate Microstructure in Cultured Vascular Smooth Muscle Cells after Exposure to Lead and Cadmium
- Induction of versican V0 variant synthesis by activation of protease-activated receptor-1 in vascular smooth muscle cells
- Vascular Smooth Muscle Cells in Culture Express Tumor Necrosis Factor-α That Suppresses Collagen Synthesis Depending on Cell Density
- Effects of Tumor Necrosis Factor-α on the Synthesis of DNA, the Secretion of Matrix Metalloproteinases/Tissue Inhibitors of Metalloproteinases, and the Activity of Invasive Migration in Cultured Vascular Smooth Muscle Cells
- Inhibition of the Association of Proteoglycans with Cultured Vascular Endothelial Cell Layers by Calcium and Sodium Spirulan
- REGULATION OF BIGLYCAN AND DECORIN SYNTHESIS BY CONNECTIVE TISSUE GROWTH FACTOR IN CULTURED BOVINE AORTIC ENDOTHELIAL CELLS
- Selective Increase in Decorin Core mRNA Level in Cultured Vascular Smooth Muscle Cells after Exposure to Advanced Glycation Endproducts
- Induction of Decorin Core Protein Synthesis by Advanced Glycation Endproducts in Cultured Vascular Smooth Muscle Cells(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Remodeling of Vascular Endothelial Glycocalyx by Basic Fibroblast Growth Factor (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- Enhancement of immediate allergic reactions by trichloroethylene ingestion via drinking water in mice
- Induction of Hepatic Metallothionein by Trivalent Cerium : Role of Interleukin 6(Pharmacology)
- HeLa Cell Transformants Overproducing Mouse Metallothionein Show in vivo Resistance to cis-Platinum in Nude Mice
- Role of Metallothionein in Protection against Renal Oxidative Stress Induced by cis-Diamminedichloroplatinum (II) in Glutathione-Depleted Mice
- Metallothionein as a Possible Antidote for Oxidative Injury
- W2-3 Metallothionein as a Possible Antidote for Oxidative Injury
- Optimum Schedule of Selenium Administration to Reduce Lethal and Renal Toxicities of cis-Diamminedichloroplatinum in Mice
- PROTECTION OF SIDE EFFECTS OF ANTICANCER DRUGS BY PRETREATMENT WITH BISMUTH COMPOUNDS
- EFFECT OF SELENITE ON RENAL TOXICITY AND ANTITUMOR ACTIVITY OF CIS-DIAMMINEDICHLOROPLATINUM IN MICE INOCULATED WITH EHRLICH ASCITES TUMOR CELL
- Permanent Waving Does not Change Mercury Concentration in the Proximal Segment of Hair Close to Scalp
- High Exposure of Chinese Mercury Mine Workers to Elemental Mercury Vapor and Increased Methylmercury Levels in Their Hair
- Effects of Hair Treatment on Hair Mercury-The Best Biomarker of Methylmercury Exposure?
- Role of metallothionein as a protective factor against radiation carcinogenesis
- Effects of Cadmium and Lead on the Release of Fibrinolytic Proteins from Vascular Endothelial Cells, Vascular Smooth Muscle Cells and Fibroblasts (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)
- Effect of Lead on the Synthesis of Tissue Plasminogen Activator by Vascular Endothelial Cells in Culture
- A Novel Transmetallation of Triarylstibanes into Arylboronate : Boro-induced Ipso-deantimonation and Its Theoretical Calculation
- An Organobismuth Compound that Exhibits Selective Cytotoxicity to Vascular Endothelial Cells in Vitro
- DNA microarray gene expression analysis of human vascular endothelial cells exposed to arsenite
- Perspectives on Cadmium Toxicity Research
- Embolic Attack in Patients With Atrial Fibrillation and Atrial Thrombus Depends on the Character of the Thrombus
- RELATIONSHIP BETWEEN TOXICITY AND CADMIUM ACCUMULATION IN RATS GIVEN LOW AMOUNTS OF CADMIUM CHLORIDE OR CADMIUM-POLLUTED RICE FOR 22 MONTHS
- Mechanism of Cadmium Stimulation on the Production of Fibrinolytic Proteins in Vascular Endothelial Cells (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- Characterization of an immortalized hepatic stellate cell line established from metallothionein-null mice
- Inhibition of Cultured Bovine Aortic Smooth Muscle Cell Proliferation by Colominic Acid(Pharmacology)
- Differential Effects of Sodium Spirulan on the Secretion of Fibrinolytic Proteins from Vascular Endothelial Cells : Enhancement of Plasminogen Activator Activity
- Trends in Growth Status among Schoolchildren in Sendai, Japan, 1994-2003 : Leveling-Off of Mean Body Height and Weight
- The Tohoku Study of Child Development : A Cohort Study of Effects of Perinatal Exposures to Methylmercury and Environmentally Persistent Organic Pollutants on Neurobehavioral Development in Japanese Children
- Atherosclerosis and Extracellular Matrix
- Induction of Plasminogen Activator Inhibitor Type 1 Synthesis by Cadmium in Human Vascular Endothelial Cells in Culture
- Proteoglycan Synthesis is Not Influenced by Zinc in Proliferating Bovine Aortic Endothelial Cells in Culture
- Disaccharide Composition of Glycosaminoglycan Chains in Growing Vascular Endothelial Cells in Culture after Exposure to Lead
- Inhibitory Effect of Rhodamine B on the Production of Glycosaminoglycans by Cultured Human Lip Fibroblasts
- Cadmium toxicity is caused by accumulation of p53 through the down-regulation of Ube2d family genes in vitro and in vivo
- Factors Affecting Hand Tremor and Postural Sway in Children
- Estimation of Daily Mercury Intake from Seafood in Japanese Women : Akita Cross-Sectional Study
- INTER-LABORATORY VALIDATION STUDY OF THE SKIN^2 DERMAL MODEL ZK1100 AND MTT CYTOTOXICITY ASSAY KITS
- INTERLABORATORY VALIDATION STUDY OF THE SKIN^2 DERMAL MODEL AND MTT CYTOTOXICITY ASSAY KITS
- Inhibitory but Reversible Effect of Rhodamine B on the Proliferation of Cultured Human Lip Fibroblasts
- Alteration of Heparan Sulfate Proteoglycans Induced by Cadmium and Lead in Cultured Vascular Endothelial Cells (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)
- Effects of Zinc on the Proliferation of Cultured Vascular Endothelial Cells and Vascular Smooth-Muscle Cells (Proceedings of the 21st Symposium on Toxicology and Environmental Health)
- Interaction between Cadmium and Zinc on Cell Damage and Its Possible Mechanisms (Proceedings of the 21st Symposium on Toxicology and Environmental Health)
- Effect of Lead on the Proliferation of Cultured Vascular Endothelial Cells and Vascular Smooth-Muscle Cells (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Effects of Cadmium on the Regulation of Blood Fibrinolysis by Vascular Endothelial Cells, Vascular Smooth-Muscle Cells and Fibroblasts (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Cadmium-Induced Alteration of Glycosaminoglycans in Cultured Vascular Endothelial Cells (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- Stimulatory Effect of Cadmium on the Release of Plasminogen Activator Inhibitor-1 from Cultured Human Vascular Endothelial Cells (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- Inhibitory Effect of Lead on the Release of Tissue Plasminogen Activator from Human Vascular Endothelial Cells in Culture (Proceedings of the 18th Symposium on Toxicology, and Environmental Health)
- Protective Effect of Zinc against Cadmium Toxicity on Cultured Vascular Endothelial Cells and Its Mechanism (Proceedings of the 18th Symposium on Toxicology, and Environmental Health)
- Decrease in the Number of Cultured Vascular Endothelial Cells by Cadmium
- DNA microarray analysis of the liver of mice treated with cobalt chloride
- 7 Efficacy of Vascular Rehabilitation and its Availability in Japan(Symposium 16 (SY-16) (H) Cardiac Rehabilitation : Innovative Approach to Improve Patient Care,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- DNA microarray analysis of human coronary artery endothelial cells exposed to cadmium
- DNA microarray analysis of normal rat kidney epithelial cells treated with cadmium
- Chronic exposure to arsenite induces S100A8 and S100A9 expression in rat RBL-2H3 mast cells
- Effect of Zinc Deficiency on the Behavior of Metallothionein-I, II Knockout Mice
- Cadmium toxicity is caused by accumulation of p53 through the down-regulation of Ube2d family genes in vitro and in vivo
- Protective effect of pretreatment with cilostazol on cytotoxicity of cadmium and arsenite in cultured vascular endothelial cells
- Suppression of Proteoglycan Synthesis by Calcium lonophore A23187 in Cultured Vascular Endothelial Cells : Implication of Intracellular Calcium Accumulation in Lead Inhibition of Endothelial Proteoglycan Synthesis
- SII-04 Molecular Mechanisms for Cadmium and Lead Toxicity in Vascular Tissue
- Mechanism of Lead Inhibition of Vascular Endothelial Cell Proliferation(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Sodium Arsenite Inhibits Proteoglycan Synthesis by Vascular Endothelial Cells in Culture
- Inhibition of the Repair of Injured Endothelial Cell Monolayers by Lead and Its Possible Mechanisms
- Cell Biological Study on Abnormal Proteoglycan Synthesis in Vascular Cells Exposed to Heavy Metals
- Effect of dental amalgam on gene expression profiles in rat cerebrum, cerebellum, liver and kidney
- Bismuth protects against arsenite-induced inhibition of proteoglycan synthesis in cultured vascular endothelial cells
- Cellular Defense Mechanisms against Lead Toxicity in the Vascular System
- Cadmium Renal Toxicity via Apoptotic Pathways
- Regulation of Proteoglycan Synthesis in Vascular Endothelial Cells by Transforming Growh Factor-β_1 Is Cell Density-Dependent
- Metallothionein deficiency exacerbates chronic inflammation associated with carcinogenesis in stomach of mice infected with Helicobacter pylori
- Microarray analysis of neonatal brain exposed to cadmium during gestation and lactation
- DNA microarray expression analysis of mouse kidney following cadmium exposure for 12 months
- A convenient method to assess chemical modification of protein thiols by electrophilic metals