Chronic exposure to arsenite induces S100A8 and S100A9 expression in rat RBL-2H3 mast cells
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the effects of chronic exposure to arsenite on the gene expression profiles of mast cells, microarray analysis was performed on rat basophilic leukemia RBL-2H3 cells exposed to arsenite for 28 days. Upregulated genes include calcium-binding S100 proteins such as S100A9, S100A10, S100A6, and S100A13, and granzymes B and C. Among S100 proteins, S100A9 showed the highest expression (8.62-fold of untreated cells) after 4-weeks of exposure to arsenite. As S100A8 and S100A9 comprise a heterodimer called calprotectin, and are implicated in the development of atherosclerosis and cancer, mRNA levels of both S100A8 and S100A9 were analyzed. The results demonstrated that exposure of RBL-2H3 cells to arsenite for a few weeks induces marked increases in mRNA levels of S100A8 and S100A9.
- 日本トキシコロジー学会の論文
- 2011-02-01
著者
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SATOH Masahiko
Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
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SEO Makoto
Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University
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Seo Makoto
Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University
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Satoh Masahiko
Laboratory Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin University
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HIMENO Seiichiro
Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunr
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Satoh Masahiko
Lab. Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin Univ.
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Satoh Masahiko
Department Of Hygienics Gifu Pharmaceutical University
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Himeno Seiichiro
Laboratory Of Molecular Nutrition And Toxicology Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Himeno S
Kitasato University School Of Pharmaceutical Sciences Department Of Public Health And Molecular Toxi
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MATSUMOTO Kanako
Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunr
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FUJISHIRO Hitomi
Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunr
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Satoh Masahiko
Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University
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Shimizu Yuri
Laboratory Of Molecular Nutrition And Toxicology Faculty Of Pharmaceutical Sciences Tokushima Bunri
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SUMI Daigo
Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunr
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Sumi Daigo
Laboratory Of Molecular Nutrition And Toxicology Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Matsumoto Kanako
Laboratory Of Molecular Nutrition And Toxicology Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Fujishiro Hitomi
Laboratory Of Molecular Nutrition And Toxicology Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Fujishiro Hitomi
Laboratory Of Molecular Nutrition And Toxicology Faculty Of Pharmaceutical Sciences Tokushima Bunri
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