Induction of Hepatic Metallothionein by Trivalent Cerium : Role of Interleukin 6(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Metallothionein (MT) is a small sulfydryl-rich protein that binds to and is inducible by heavy metals such as mercury, cadmium, zinc, and copper. However, little is known about the induction of MT by trivalent metals except for bismuth. In this study, we examined the induction of MT synthesis by cerium, a trivalent lanthanoid metal. Administration of cerium chloride (CeCl_3) to mice resulted in accumulation of cerium and induction of MT in the liver in a dose-dependent manner. Distribution profiles of metals in the soluble fraction of the liver of CeCl_3-treated mice analyzed by high performance liquid chromatography/inductively coupled argon plasmamass spectrometry (HPLC/ICP-MS) demonstrated that the metal bound to MT-I and MT-II was zinc, but not cerium. Administration of CeCl_3 caused increases in the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and the levels of serum amyloid A (SAA), an acute phase protein. Among inflammatory cytokines examined, interleukin 6 (IL-6) exhibited a marked increase in the serum at 3h after the CeCl_3 administration. In order to evaluate the involvement of IL-6 in the induction of MT by cerium, we examined MT induction by CeCl_3 in IL-6 null mice. Both the induction of hepatic MT and the increases in SAA levels were markedly suppressed in IL-6 null mice. These results suggest that IL-6 plays an important role in the induction of hepatic MT by cerium.
- 社団法人日本薬学会の論文
- 2005-10-01
著者
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Tohyama Chiharu
Environmental Health Sciences Division, National Institute for Environmental Studies
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KURODA Junji
Toxicology Laboratory, Kissei Pharmaceutical Co., Ltd.
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SHIBATA Nobuo
Research and Development Division, Kissei Pharmaceutical Co. Ltd.
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HASEGAWA Tatsuya
Department of Environmental Biochemistry, Yamanashi Institute of Environmental Sciences
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SEKO Yoshiyuki
Department of Environmental Biochemistry, Yamanashi Institute of Environmental Sciences
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SATOH Masahiko
Department of Hygienics., Gifu Pharmaceutical University
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Seko Yoshiyuki
徳島文理大学 薬学部衛生化学
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Seko Yoshiyuki
Dep. Of Environmental Biochemistry Yamanashi Inst. Of Environmental Sciences
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Seko Yoshiyuki
Department Of Environmental Biochemistry Yamanashi Institute Of Environmental Sciences
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Imura Nobumasa
Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato Un
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Imura Nobumasa
Dep. Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ.
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Imura Nobumasa
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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KOBAYASHI Kazuo
Toxicology Research Laboratory, R&D, Kissei Pharmaceutical Co., Ltd.
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SHIDA Rumi
Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato Un
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SHIBATA Nobuo
Toxicology Research Laboratory, R&D, Kissei Pharmaceutical Co., Ltd.
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HIMENO Seiichiro
Department of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunr
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Shida Rumi
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Kuroda Junji
Toxicology Lab. Kissei Pharmaceutical Co. Ltd.
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Kuroda J
Toxicology Research Laboratory R&d Kissei Pharmaceutical Co. Ltd.
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Kuroda Junji
Toxicology
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Satoh Masahiko
Department Of Hygienics Gifu Pharmaceutical University
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Imura N
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Tohyama Chiharu
Division Of Environmental Health Sciences Center For Disease Biology And Integrative Medicine Gradua
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Tohyama Chiharu
Environmental Health Sciences Division National Institute For Environmental Studies:department Of Hy
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Tohyama Chiharu
Environmental Health Sciences Division National Institute For Environmental Studies:center For Disea
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Tohyama Chiharu
Environmental Health Science Division National Institute For Environmental Studies
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Himeno Seiichiro
Department Of Molecular Nutrition And Toxicology Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Himeno Seiichiro
Department Of Human Ecology School Of Health Sciences Faculty Of Medicine University Of Tokyo
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Hasegawa Tatsuya
Department Of Environmental Biochemistry Yamanashi Institute Of Environmental Sciences
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Shibata Nobuo
Research And Development Division Kissei Pharmaceutical Co. Ltd.
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Shibata Nobuo
Toxicology Research Laboratory Kissei Pharmaceutical Co. Ltd.
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Shibata Nobuo
Toxicology Research Laboratory R&d Kissei Pharmaceutical Co. Ltd.
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Kuriyama Kazuya
Toxicology Research Laboratories Kissei Pharmaceutical Co. Ltd.
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Tohyama C
Environmental Health Sciences Division National Institute For Environmental Studies:center For Disea
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Tohyama Chiharu
Environ Health Sci Div. Nat'l Inst Environ. Studies
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Hasegawa Tatsuya
Faculty Of Pharmaceutical Sciences Setsunan University
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Imura Nobumasa
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Tohyama Chiharu
Division Of Environmental Health Sciences Center For Disease Biology And Integrative Medicine Gradua
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Kobayashi Kazuo
Pharmacodynamics Research Laboratories Sankyo Co. Ltd.
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Hasegawa Tatsuya
Dep. Of Environmental Biochemistry Yamanashi Inst. Of Environmental Sciences
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Kobayashi Kazuo
Toxicology Research Laboratory, R & D, Kissei Pharmaceutical Co., Ltd.
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KOBAYASHI Kazuo
Toxicology Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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