Optimum Schedule of Selenium Administration to Reduce Lethal and Renal Toxicities of cis-Diamminedichloroplatinum in Mice
スポンサーリンク
概要
- 論文の詳細を見る
The optimum conditions of selenium administration to reduce the side effects of a single dose of cis-diamminedichloroplatinum (cis-DDP) in mice were examined. The best effects against lethal toxicity of cis-DDP was obtained when sodium selenite was administered subcutaneously (s.c.) to mice simultaneously with s.c. injected cis-DDP at a molar ratio of 1 to 3.5 (sodium selenite to cis-DDP) on the first day and the same amount of selenite was given daily for four subsequent days. This coadministration of selenite completely depressed not only lethal toxicity of cis-DDP but also its renal toxicity (indicated by increased blood urea nitrogen values) and intestinal toxicity (indicated by the incidence of diarrhea) which were usually observed in the mice treated with cis-DDP alone. Furthermore, coadministration of selenite did not compromise the antitumor activity of cis-DDP against several transplantable tumors in mice. Therefore, the administration schedule of selenite with cis-DDP described above may be useful for cancer chemotherapy.
- 社団法人日本薬学会の論文
著者
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SATOH Masahiko
Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
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SATOH Masahiko
Department of Hygienics., Gifu Pharmaceutical University
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Imura Nobumasa
Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato Un
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Imura Nobumasa
Dep. Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ.
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Imura Nobumasa
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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NAGANUMA Akira
Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato Un
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Naganuma Akira
Department Of Molecular And Biochemical Toxicology Faculty Of Pharmaceutical Sciences Tohoku Univers
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Satoh Masahiko
Laboratory Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin University
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Satoh Masahiko
Department Of Hygienics Gifu Pharmaceutical University
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Imura N
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Naganuma Akira
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Naganuma A
Tohoku Univ. Sendai Jpn
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Naganuma Akira
Dept. Of Public Health School Of Pharmaceutical Sciences Kitasato University
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Naganuma Akira
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku
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Naganuma Akira
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Imura Nobumasa
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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