Accumulation and Toxicity of Orally Ingested Cadmium in Metallothionein Null Mice
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the role of metallothionein (MT) on the accumulation and toxicity of orally administered cadmium (Cd), metallothionein null and 129/Sv mice were fed a Cd-containing diet (50ppm) for four months. Cd concentrations in the liver and kidney of MT null mice did not exceed 10μg/g throughout the exposure period, while a time-dependent increase in tissue Cd concentrations was observed in the control mice. However, no apparent nephrotoxicity was observed in MT null mice, as is contrary to previous observations in which repeated subcutaneous injections of Cd caused renal dysfunction in MT null mice, though the renal Cd concentrations did not exceed 10μg/g. The results of this study suggest that the route of Cd administration plays an important role in the manifestation of Cd nephrotoxicity, even in the absence of MT.
- 2000-04-01
著者
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Imura Nobumasa
Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato Un
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Imura Nobumasa
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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HIMENO Seiichiro
Department of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunr
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Himeno Seiichiro
Department Of Human Ecology School Of Health Sciences Faculty Of Medicine University Of Tokyo
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Yamazaki Yukie
Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato Un
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Himeno Seiichiro
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Imura Nobumasa
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Yamazaki Yukie
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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