Characterization of cis-Diamminedichloroplatinum(II)-Resistant Murine Cell Lines Derived from Metallothionein Null Cells
スポンサーリンク
概要
- 論文の詳細を見る
Metallothionein(MT)is known to play an important role in the resistance of tumor cells to cisdiamminedichloroplatinum(II)(CDDP, cisplatin). To identify non-MT factors that play important roles in CDDP resistance, we established CDDP-resistant cell lines from simian virus 40-transformed MT null cells. Subclones of CDDP-resistant MT null cells, designated as MKCr-3, -12, and -18, exhibited 24- to 62-fold resistance to CDDP compared with parental cells. The contents of glutathione(GSH)and the activities of GSH-related enzymes and antioxidant enzymes in MKCr-12 and -18 were higher than those in parental cells. However, MKCr-3 cells did not show any significant increase in the levels of GSH nor in enzyme activities except for superoxide dismutase. Accumulation of platinum in CDDP-resistant subclones was l5-26% of that in parental cells 24 h after administration of CDDP. Eleven other subclones of CDDP-resistant MT null cells also exhibited low accumulation of platinum. These results suggest that the decreased accumulation of CDDP may be a predominant factor in the resistance to CDDP in the absence of MT, an intracellular metal- and free radical-scavenger.
- 社団法人日本薬学会の論文
- 2001-08-01
著者
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HASEGAWA Tatsuya
Department of Environmental Biochemistry, Yamanashi Institute of Environmental Sciences
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SEKO Yoshiyuki
Department of Environmental Biochemistry, Yamanashi Institute of Environmental Sciences
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Seko Yoshiyuki
徳島文理大学 薬学部衛生化学
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Seko Yoshiyuki
Dep. Of Environmental Biochemistry Yamanashi Inst. Of Environmental Sciences
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Seko Yoshiyuki
Department Of Environmental Biochemistry Yamanashi Institute Of Environmental Sciences
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KONDO Yukihiro
Department of Urology, Nippon Medical School
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Imura Nobumasa
Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato Un
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Imura N
Kitasato Univ Tokyo Jpn
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Imura Nobumasa
Dep. Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ.
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Imura Nobumasa
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Kondoh Yukihiro
千葉大学 医学研究院泌尿器科
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Kondo Y
Nippon Medical School Department Of Urology
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HIMENO Seiichiro
Department of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunr
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Yamabe Yukako
Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato Un
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Endo Wakako
Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato Un
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Sasaya Kayo
Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato Un
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Endo Wakako
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Sasaya Kayo
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Yamabe Yukako
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Himeno Seiichiro
Department Of Molecular Nutrition And Toxicology Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Himeno Seiichiro
Department Of Human Ecology School Of Health Sciences Faculty Of Medicine University Of Tokyo
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Hasegawa Tatsuya
Department Of Environmental Biochemistry Yamanashi Institute Of Environmental Sciences
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Kondoh Yukihiro
Department Of Urology Nippon Medical School
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Kondo Yukihiro
Department Of Urologic Surgery Graduate School Of Medicine Nippon Medical School
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Himeno S
Kitasato University School Of Pharmaceutical Sciences Department Of Public Health And Molecular Toxi
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Hasegawa Tatsuya
Faculty Of Pharmaceutical Sciences Setsunan University
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Kondoh Yukihiro
Departments Of Urology Nippon Medical School
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Hasegawa Tatsuya
Dep. Of Environmental Biochemistry Yamanashi Inst. Of Environmental Sciences
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