Cyclooxygenase-2 Expression and Relationship to Malignant Potential in Human Bladder Cancer
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概要
- 論文の詳細を見る
Cyclooxygenase (COX), which catalyzes the synthesis of prostaglandins from arachidonic acid, has two isoforms ; COX- 1 and COX-2. A large body of evidence exists to suggest that COX-2 is important in gastrointestinal cancer. In order to determine whether COX-2 is expressed in transitional cell carcinoma (TCC) of the human bladder as well as in gastrointestinal cancer, we investigated COX-2 expression in human TCC by Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and immunohistochemical analysis, and we found that normal bladder epithelium did not express COX-2 and that COX-2 was markedly up-regulated in human bladder TCC. In nontumor tissues, COX-2 immunostaining signals were observed only in lymphoid follicles. Furthermore, the intensity and extent of COX-2 immunostaining in the bladder cancer tissues were scored and the relationship to tumor grade and stage was investigated. The levels of COX-2 expression were correlated with the tumor grade ; from grades l to 3,there was a stepwise increase in the COX-2 immunostaining score. These findings suggested that an increase in COX-2 expression may be associated with bladder carcinogenesis as well as gastrointestinal carcinogenesis, and that it may be useful as a biomarker in bladder cancer.
- 社団法人日本薬学会の論文
- 2002-02-01
著者
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Matsuzawa Ichiro
Department Of Urology Nippon Medical School
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KONDO Yukihiro
Department of Urology, Nippon Medical School
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KIMURA Go
Department of Urology, Nippon Medical School
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Hashimoto Yoshitaka
Department of Urology, Nippon Medical School
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Horie Shigeo
Department of Urology, Faculty of Medicine, University of Tokyo
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Imura Nobumasa
Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato Un
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Akimoto Masao
Department of Urology, Nippon Medical School
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Hara Shuntaro
Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato Un
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Imura Nobumasa
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Kimura Go
Department Of Urology Nippon Medical School
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Kimura Go
Department Of Molecular Genetics Beckman Research Institute Of The City Of Hope
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Kondoh Yukihiro
千葉大学 医学研究院泌尿器科
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Hara Shuntaro
Department Of Health Chemistry School Of Pharmaceutical Sciences Showa University
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Hara Shuntaro
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Hashimoto Yoshitaka
Department Of Urology Nippon Medical School
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Hashimoto Yoshitaka
Department Of Natural Environmental Science Kochi University
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Akimoto Masao
Department Of Urology Nippon Medical School
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Akimoto Masao
Department Of Urology Center For Advanced Medical Technology Nippon Medical School
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Horie Shigeo
Department Of Biochemistry Kitasato University School Of Medicine
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Ishihara Masaharu
Department Of Urology Chiba University Graduate School Of Medicine
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Akimoto Masao
Departments Of Urology Nippon Medical School
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Horie Shigeo
Department Of Urology Faculty Of Medicine University Of Tokyo
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Kondoh Yukihiro
Department Of Urology Nippon Medical School
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Kondo Yukihiro
Department Of Urologic Surgery Graduate School Of Medicine Nippon Medical School
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Kimura Go
Departments Of Urology Nippon Medical School
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Imura Nobumasa
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Kondoh Yukihiro
Departments Of Urology Nippon Medical School
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