Nicorandil, a Potassium Channel Opener and Nitric Oxide Donor, Improves the Frequent Urination without Changing the Blood Pressure in Rats with Partial Bladder Outlet Obstruction(Pharmacology)
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概要
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It was studied to determine if nicorandil can improve frequent urination in rats with partial bladder outlet obstruction (BOO) without changing the blood pressure. Materials and methods: Voiding behavior was observed 6 to 8d after obstruction in female rats with BOO that loaded 30ml/kg of water. A drug was administered orally. Changes in systemic blood pressure and heart rate were studied in conscious BOO rats using the tail cuff method. Results: The voiding frequency was increased and the average voided volume was decreased in BOO rats compared with normal rats. Nicorandil (1mg/kg), cromakalim (0.1mg/kg) and isosorbide dinitrate (ISDN; 1000mg/kg) decreased voiding frequency significantly in BOO rats. Nicorandil also increased the average voided volume significantly. Although cromakalim and ISDN at doses effective at decreasing voiding frequency caused blood pressure to drop, nicorandil at an effective dose did not affect blood pressure and heart rate. Conclusion: Nicorandil improved frequent urination without changing the blood pressure. These results suggested that a hybrid of a K_<ATP> channel opener and nitric oxide donor, nicorandil was bladder-selective compared with vasculature in BOO rats.
- 2008-11-01
著者
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Horie Shigeo
Department of Urology, Faculty of Medicine, University of Tokyo
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Horie Shigeo
Department Of Urology Teikyo University School Of Medicine
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Horie Shigeo
Department Of Biochemistry Kitasato University School Of Medicine
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Otsuka Hideaki
Graduate School of Biomedical Sciences, Hiroshima University
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Otsuka Hideaki
Graduate School Of Biomedical Sciences Hiroshima University
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SUDO Hirokazu
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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YOGO Kenji
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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ISHIZUKA Nobuhiko
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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SAITO Keiji
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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Yogo Kenji
Product Research Department Chugai Pharmaceutical Co. Ltd.
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Sudo Hirokazu
Product Research Department Chugai Pharmaceutical Co. Ltd.
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Saito Keiji
Fuji-gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
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HORIE Shigeo
Department of Urology, Teikyo University School of Medicine
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Otsuka Hideaki
Graduate School of Biomedical and Health Sciences, Hiroshima University
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