Structure-Activity Study of Intact Porcine Motilin
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概要
- 論文の詳細を見る
Biologically important sites on intact porcine motilin (pMTL) were explored using its partial peptides. The partial peptides were synthesized using Fmoc (9-fluorenylmethyloxycarbonyl) solid phase methodology, and tested for the binding activity to motilin receptor and the smooth muscle contractile activity. The results were as follows : important residues for the contractile activity were found to be Phe^1,Ile^4,and Tyr^7,and an open space existed beyond the N-terminus between motilin and its receptor. On the model of interaction between motilin and motilin receptor evolved from these results, the three points of interaction, due to Phe^1,Ile^4,and Tyr^7,and the presence of an open space were expected. The motilin agonist and antagonist, designed on this model, will help the inquiry into motilin associated diseases.
- 公益社団法人日本薬学会の論文
- 1999-11-15
著者
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TAKANASHI Hisanori
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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YOGO Kenji
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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Yogo K
Fuji-gotemba Research Laboratories Chugai Pharmaceutical Co.ltd.
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Otaka A
Kyoto Univ. Kyoto Jpn
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Ikuta Makoto
Fuji-gotemba Research Laboratories Chugai Pharmaceutical Co.ltd.
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Okamachi A
Fuji-gotemba Research Laboratories Chugai Pharmaceutical Co.ltd.
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Murayama E
Fuji-gotemba Research Laboratories Chugai Pharmaceutical Co.ltd.
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HARAMURA Masayuki
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co.Ltd.
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OKAMACHI Akira
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co.Ltd.
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TSUZUKI Kouichi
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co.Ltd.
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KOZONO Toshiro
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co.Ltd.
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MURAYAMA Eigoro
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co.Ltd.
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Okamachi Akira
Fuji-gotemba Research Laboratories Chugai Pharmaceutical Co.ltd.
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Kozono Toshiro
Fuji-gotemba Research Laboratories Chugai Pharmaceutical Co.ltd.
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Tsuzuki K
Fuji-gotemba Research Laboratories Chugai Pharmaceutical Co.ltd.
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Haramura Masayuki
Fuji-gotemba Research Laboratories Chugai Pharmaceutical Co.ltd.
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Takanashi H
Fuji-gotemba Research Laboratories Chugai Pharmaceutical Co.ltd.
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Takanashi Hisanori
Fuji-gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
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