STUDIES ON THE ACCELERATING EFFECT OF THIAMINE AND ITS DERIVATIVES ON YEAST FERMENTATION
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概要
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1. Using Atkin-Schultz-Frey's microbiological assay for thiamine based on the accelerating effect of thiamine on yeast fermentation, the effect of thiamine and of 24 derivatives on anaerobic decarboxylation was examined.2. This method can be applied as a biological test of thiamine derivatives, if it is taken into consideration that the action on yeast is not always in agreement with that on animals.3. Following thiamine derivatives were examined; (a) S, S-alkyl derivatives show the accelerating effect as much as, or a little more than, thiamine. (b) Of O, S-diacyl thiamines, O, S-diacetyl thiamine is as active as thiamine and the effects of other compounds appeared in the following decreasing order.O, S-Diacetyl>dipropionyl>S-propionyl-O-benzoyl>dibenzoyl. Once the effects have appeared, they were all as active as thiamine. (c) O-Acyl derivatives were somewhat inferior to thiamine. (d) S-Alkyl derivatives have generally little activity, if any. (e) Thiothiamines have no activity. (f) As antivitamins, hydroxythiamine, butylthiamine and heteropyrithiamine were examined, of which hydroxythiamine alone showed a slight antithiamine activity.4. As for the mechanism of accelerating effect, the relation to nirogen metabolism is important, and the effect of nitrogen sources, increase in nitrogen in cells and promotion of budding were observed. Further, participation of metal ions and the permeability of cell membrane were observed.
- 日本ビタミン学会の論文
著者
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Horie Shigeo
Department Of Biochemistry Kitasato University School Of Medicine
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HORIE SHIGEO
Department of Biochemistry, Faculty of Medicine, University of Tokyo
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SHIMAZONO NORIO
Department of Biochemistry, Faculty of Medicine, University of Tokyo
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OKOSHI KUMIKO
Department of Biochemistry, Faculty of Medicine, University of Tokyo
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SHINOHARA TSUNEKI
Department of Biochemistry, Faculty of Medicine, University of Tokyo
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ORIKABE EIJI
Department of Biochemistry, Faculty of Medicine, University of Tokyo
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