Cytotoxic Diterpenoids from Vietnamese Medicinal Plant Croton tonkinensis GAGNEP
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概要
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Six new ent-kaurane-type diterpenoids were isolated from the leaves of the endemic Vietnamese medicinal plant Croton tonkinensis GAGNEP. (Euphorbiaceae) together with three known ent-11α-acetoxy-7β, 14α-dihydroxykaur-16-en-15-one (1), ent-kaur-16-en-15-one 18-oic acid (5) and ent-18-hydroxykaur-16-ene (7). Their structures were determined by spectroscopic analyses to be ent-7β-acetoxy-11α-hydroxykaur-16-en-15-one (2), ent-18-acetoxy-11α-hydroxykaur-16-en-15-one (3), ent-11α-acetoxykaur-16-en-18-oic acid (4), ent-15α, 18-dihydroxykaur-16-ene (6), ent-11α, 18-diacetoxy-7β-hydroxykaur-16-en-15-one (8), and ent-(16S)-1α, 14α-diacetoxy-7β-hydroxy-17-methoxykauran-15-one (14). ent-Kaurane-type diterpenoids from Croton tonkinensis 2-4, 6, and 9-13, were tested for toxicity in the brine shrimp lethality assay. Compounds 9, 10, and 12 demonstrated significant activity, compounds 2, 3, 6, and 11 showed weak activity, and compounds 4 and 13 were inactive.
- 社団法人日本薬学会の論文
- 2005-03-01
著者
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Giang Phan
Faculty Of Chemistry College Of Natural Science Vietnam National University
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Otsuka Hideaki
Dep. Of Pharmacognosy Graduate School Of Biomedical Sciences Hiroshima Univ. 1-2-3 Kasumi Minami-ku
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Otsuka Hideaki
Graduate School of Biomedical Sciences, Hiroshima University
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Son Phan
Faculty Of Chemistry College Of Natural Science Vietnam National University
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Otsuka Hideaki
Graduate School Of Biomedical Sciences Hiroshima University
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HAMADA Yumi
Graduate School of Biomedical Sciences, Hiroshima University
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Hamada Yumi
Graduate School Of Biomedical Sciences Hiroshima University
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Son Phan
Vietnam National Univ. Hanoi Vnm
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Giang Phan
Vietnam National Univ. Hanoi Vnm
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Otsuka Hideaki
Graduate School of Biomedical and Health Sciences, Hiroshima University
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