Mapping of a New Target Region of Allelic Loss to a 6-cM Interval at 21q21 in Primary Breast Cancers

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概要

• 論文の詳細を見る

• A detailed analysis of loss of heterozygosity (LOH) in breast cancers was performed with 11 microsatellite markers on the long arm of chromosome 21. Among the 142 tumors examined, 44 (31%) showed LOH at one or more loci. Peak LOH frequency was observed on band 21q21. Deletion mapping identified a new commonly deleted region in a 6-cM interval of 21q21 between loci D21S1432 and D21S1437,and raised the possibility that one or more tumor suppressor genes associated with breast cancer may exist in this region. Comparison of these alterations with clinicopathological parameters revealed an association of LOH on 21q with loss of progesterone receptor (P=0.0013). Genes Chromosomes Cancer 23 : 244-247,1998.

• 日本医科大学の論文
• 1999-03-25

著者

• Emi Mitsuru

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Sakamoto Goi

  Department of Surgery and Pathology, Cancer Institute Hospital

• Kasumi Fujio

  Department of Surgery and Pathology, Cancer Institute Hospital

• Nakamura Yusuke

  Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of T

• Iida Aritoshi

  東京大学医科学研究所ヒトゲノム解析センター

• Aritoshi Iida

  Laboratory For Pharmacogenetics Snp Research Center The Institute Of Physical And Chemical Research

• Iida A

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Iida Aritoshi

  理化学研究所遺伝子多型研究センター

• Nakamura Y

  東京大学医科学研究所ヒトゲノム解析センター ゲノムシークエンス解析分野

• Akimoto Masao

  Department of Urology, Nippon Medical School

• Fukino K

  Department Of Breast Surgery The Cancer Institute Hospital Of Jfcr

• Kasumi Fujio

  Department Of Breast Surgery Cancer Institute Hospital

• Iida Aritoshi

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Akimoto Masao

  Department Of Urology Nippon Medical School

• Akimoto M

  Nippon Medical School Tokyo

• Akimoto Masao

  Department Of Urology Center For Advanced Medical Technology Nippon Medical School

• Emi Mitsuru

  Department Of Biochemistry Cancer Institute

• OHGAKI Kenji

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Kasumi Fujio

  Department Of Breast Surgery The Cancer Institute Hospital Of Jfcr

• Sakamoto Goi

  Department Of Breast Pathology The Cancer Institute Of Japanese Foundation For Cancer Research

• Sakamoto Goi

  Department Of Breast Pathology Cancer Institute

• Iida Aritoshi

  Laboratory For Genotyping Riken Snp Research Center C/o Institute Of Medical Science The University

• Iida Aritoshi

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Ohgaki Kenji

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Nakamura Yusuke

  Laboratory For Molecular Medicine Human Genome Center The Institute Of Medical Science University Of

• Iida Aritoshi

  Laboratory For Bone And Joint Diseases Center For Genomic Medicine Riken

• Nakamura Yusuke

  Laboratory Of Molecular Medicine Human Genome Center Institute Of Medical Science University Of Toky

• Nakamura Yusuke

  Laboratory For Genotyping Riken Snp Research Center C/o Riken Yokohama Institute

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