Identification of a 1-cM Region of Common Deletion on 4q35 Associated With Progression of Hepatocellular Carcinoma

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概要

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• To identify the location of one or more of the putative tumor suppressor genes (TSG) on chromosome arm 4q that may be involved in hepatocellular carcinoma (HCC), we examined 96 primary HCCs for their patterns of allelic loss at 39 microsatellite marker loci distributed along this chromosome arm. Allelic loss at one or more loci was observed in 71 (74%) HCCs. Detailed deletion mapping identified two distinct commonly deleted regions; one was located within a 1-cM interval flanked by D4S1534 and D4S2929 at 4q21-22,the other in the 1-cM interval flanked by D4S2921 and D4S2930 at 4q35. Of the tumors for which clinical data were available, allelic loss at 4q35 was more frequent in poorly or moderately differentiated tumors than in well-differentiated tumors (3/15,20%, vs. 14/21,67%, P=0.008); in tumors larger than 2cm in size (2/11,18%, vs. 34/62,55%, P=0.046); and in tumors that arose from liver cirrhosis as opposed to HCCs arising from chronic hepatitis (25/42,60%, vs. 9/27,33%, P=0.048). The association of allelic losses on 4q35 with larger tumor size and aggressive histological type implies that loss or inactivation of TSG located within the 1-cM interval of 4q35 identified here contribute to progression of HCCs.

• 日本医科大学の論文
• 2000-03-25

著者

• Emi Mitsuru

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Nagai Hisaki

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Matsumoto Satoshi

  Department Of Pathology Nara Medical University

• Nagai H

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Nagai Hisaki

  日本医科大学老人病研究所

• Nagai H

  Department Of Surgery Tokyo Women's Medical University Daini Hospital

• Nagai Hisaki

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Onda Masahiko

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Bando Koichi

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Koyama Masaaki

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Kawamura Naoki

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Onda Masahiko

  First Department of Surgery, Nippon Medical School

• Kawamura N

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Kawamura Naoki

  Department Of Computer Science The University Of Electro-communications:(present Address)tokyo Techn

• Koyama Masaaki

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Emi Mitsuru

  Department Of Biochemistry Cancer Institute

• Nishi Hirofumi

  Cardiovascular Center Kurume University

• Bando Koichi

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School:first Department Of S

• Bando Koichi

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Onda Masahiko

  First Department Of Surgery Nippon Medical School

• Shimizu Masashi

  Department Of Pathology Nara Medical University

• Bando Kouichi

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Matsumoto Satoshi

  Department Of Neurological Surgery Kobe University School Of Medicine

• Saito Mitsue

  Department Of Breast Surgery Cancer Institute Hospital

• Matsumoto Satoshi

  Department Of Electrical Electronic And Computer Engineering The Kyushu Institute Of Technology

• Matsumoto Satoshi

  Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University

• Matsumoto Satoshi

  Department Of Agricultural Chemistry University Of Tokyo

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