Detailed Deletion Mapping of Chromosome Arm 3p in Breast Cancers : A 2-cM Region on 3p 14.3-21.1 and a 5-cM Region on 3p 24.3-25.1 Commonly Deleted in Tumors

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概要

• 論文の詳細を見る

• Loss of heterozygosity (LOH) on 3p is frequent in human renal cell carcinomas, lung cancers, and breast cancers. To define the region (s) on 3p that harbor presumptive tumor suppressor gene (s) for breast cancer, we examined 196 primary breast tumors for their patterns of LOH at 22 microsatellite marker loci distributed along this chromosome arm. Allelic loss at one or more loci was observed in 101 (52%) of these tumors. Detailed deletion mapping identified two distinct commonly deleted regions; one was localized to a 2-cM interval flanked by D3S1547 and D3S1295 at 3p 14.3-21.1,and the other to a 5-cM interval flanked by D3S1286 and D3S1585 at 3p 24.3-25.1. The FHIT gene lies in the vicinity of the proximal commonly deleted region. Attempts to correlate LOH on 3p to clinicopathological parameters detected an association with the absence of the progesterone receptor (P=0.0096). The results suggest that inactivation of unidentified tumor suppressor genes on 3p plays a role in the mechanism whereby hormone dependency is lost in the course of breast carcinogenesis. Genes Chromosomes Cancer 20 : 268-274,1997.

• 日本医科大学の論文
• 1998-03-25

著者

• Emi Mitsuru

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Sakamoto Goi

  Department of Surgery and Pathology, Cancer Institute Hospital

• Kasumi Fujio

  Department of Surgery and Pathology, Cancer Institute Hospital

• Nakamura Yusuke

  Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of T

• Matsumoto Satoshi

  Department Of Pathology Nara Medical University

• Onda Masahiko

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Fukino K

  Department Of Breast Surgery The Cancer Institute Hospital Of Jfcr

• Kasumi Fujio

  Department Of Breast Surgery Cancer Institute Hospital

• Onda Masahiko

  First Department of Surgery, Nippon Medical School

• Emi Mitsuru

  Department Of Biochemistry Cancer Institute

• Sakamoto Goi

  Department Of Breast Pathology The Cancer Institute Of Japanese Foundation For Cancer Research

• Sakamoto Goi

  Department Of Breast Pathology Cancer Institute

• Onda Masahiko

  First Department Of Surgery Nippon Medical School

• Nakamura Yusuke

  Laboratory For Molecular Medicine Human Genome Center The Institute Of Medical Science University Of

• Shimizu Masashi

  Department Of Pathology Nara Medical University

• Matsumoto Satoshi

  Department Of Neurological Surgery Kobe University School Of Medicine

• Saito Mitsue

  Department Of Breast Surgery Cancer Institute Hospital

• Nakamura Yusuke

  Laboratory Of Molecular Medicine Human Genome Center Institute Of Medical Science University Of Toky

• Matsumoto Satoshi

  Department Of Electrical Electronic And Computer Engineering The Kyushu Institute Of Technology

• Nakamura Yusuke

  Laboratory For Genotyping Riken Snp Research Center C/o Riken Yokohama Institute

• Matsumoto Satoshi

  Department Of Agricultural Chemistry University Of Tokyo

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