Allelic Loss at 1p34-36 Predicts Poor Prognosis in Node-negative Breast Cancer

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概要

• 論文の詳細を見る

• Allelic losses of specific chromosomal regions in the DNA of tumor cells, which imply loss of tumor suppressor genes normally resident at those loci, may become useful postoperative prognostic indicators for breast cancers that have not yet metastasized to lymph nodes. To examine whether specific allelic losses might correlate with postoperative disease-free survival, we tested tumors from a cohort of 228 node-negative breast cancer patients for allelic losses at 18 microsatellite loci chosen to represent either a known tumor suppressor gene or a region where genetic alterations are frequent in breast tumors. We followed the patients clinically for 5 years or until death (if patient death occurred before completion of 5 years of follow-up). Patients whose tumors had lost an allele at 1p34-36 bore significantly higher risks of postoperative recurrence than those whose tumors retained both alleles of the markers in that region [the 5-year recurrence rate was 15% among patients with losses versus 2% among patients with retention (P=0.001)]. Multivariate analysis demonstrated that allelic loss at 1p34-36 was an independent postoperative predictor of shorter disease-free survival (hazard ratio, 5.8; P=0.0117). Thus, allelic losses at 1p34-36 in a tumor might have a potential to serve as a negative prognostic indicator to guide postoperative management of breast cancer patients, especially in the selection of high-risk women who will benefit from adjuvant chemotherapy and endocrine therapy.

• 日本医科大学の論文
• 2001-03-25

著者

• Emi Mitsuru

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Sakamoto Goi

  Department of Surgery and Pathology, Cancer Institute Hospital

• Kasumi Fujio

  Department of Surgery and Pathology, Cancer Institute Hospital

• 梶原 哲郎

  Tochigi Cancer Center Hospital

• 梶原 哲郎

  東京女子医科大学第二病院外科

• 三木 義男

  癌研ゲノムセンター

• Nakamura Yusuke

  Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of T

• Katagiri Toyomasa

  京都大学 医学部外科学

• Emi M

  Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School

• Akiyama Fumihiro

  Human Genome Center The Institute Of Medical Science University Of Tokyo

• Kodama Tetsuro

  栃木県立がんセンター研究所 がん遺伝子研究室

• HAGA Shunsuke

  Department of Surgery, Tokyo Women's Medical University Daini Hospital.

• UTADA Yoshihito

  Department of Surgery, Tokyo Women's Medical University Daini Hospital.

• KAJIWARA Tetsuro

  Department of Surgery, Tokyo Women's Medical University Daini Hospital.

• Yoshimoto M

  The Cancer Institute Of Japanese Foundation For Cancer Research (jfcr)

• Matsumoto-mishima Yuko

  癌研究会癌化学療法センター 臨床研究部

• Yoshimoto Masataka

  Department of Surgery and Pathology, Cancer Institute

• Akiyama Futoshi

  Department of Surgery and Pathology, Cancer Institute

• Nakamura Y

  東京大学医科学研究所ヒトゲノム解析センター ゲノムシークエンス解析分野

• Fukino K

  Department Of Breast Surgery The Cancer Institute Hospital Of Jfcr

• Kasumi Fujio

  Department Of Breast Surgery Cancer Institute Hospital

• Emi Mitsuru

  Department Of Biochemistry Cancer Institute

• Haga Shunsuke

  Department Of Surgery Tokyo Women's Medical University Daini Hospital

• Emi Mitsuru

  Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School

• Kasumi Fujio

  Department Of Breast Surgery The Cancer Institute Hospital Of Jfcr

• Sakamoto Goi

  Department Of Breast Pathology The Cancer Institute Of Japanese Foundation For Cancer Research

• Sakamoto Goi

  Department Of Breast Pathology Cancer Institute

• Utada Yoshihito

  Department Of Surgery Tokyo Women's Medical University Daini Hospital

• Kajiwara Tetsuro

  Department Of Surgery Tokyo Women's Medical College Daini Hospital

• Akiyama Futoshi

  Division Of Pathology Cancer Institute Of Japanese Foundation For Cancer Research

• Akiyama Futoshi

  Department Of Breast Pathology Cancer Institute And Hospital Japanese Foundation For Cancer Research

• Nakamura Yusuke

  Laboratory For Molecular Medicine Human Genome Center The Institute Of Medical Science University Of

• Nakamura Yusuke

  Univ. Tokyo Tokyo Jpn

• Nakamura Yusuke

  Laboratory Of Molecular Medicine Human Genome Center Institute Of Medical Science University Of Toky

• Nakamura Yusuke

  Laboratory For Genotyping Riken Snp Research Center C/o Riken Yokohama Institute

• Yoshimoto Masataka

  Department Of Molecular Diagnosis Cancer Institute Japanese Foundation For Cancer Research

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