Linkage of interleukin 6 locus to human osteopenia by sibling pair analysis

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概要

• 論文の詳細を見る

• Osteopenia and osteoporosis are common human conditions considered to result from the interplay of multiple genetic and environmental factors. Twin and family studies have yielded strong correlations between levels of bone mass and a number of genetic factors. The genes involved could regulate metabolism, formation and resorption of bone, all processes that determine bone mass. We tested 192 sibling pairs of adult Japanese women from 136 families for genetic linkage between osteopenia and allelic variants of four candidate genes (interleukin-6,interleukin-6 receptor, calcium-sensing receptor, and matrix gla protein) using qualitative and quantitative methods, and using as genetic markers dinucleotide-repeat polymorphisms present in or near each of those loci. The interleukin-6 locus showed evidence of linkage to osteopenia analyzed as a qualitative trait, with mean allele sharing of 0.40 (P=0.0001) in discordant pairs and 0.55 (P=0.04) in concordant affected pairs. Variation at this locus was also linked to decreased bone mineral density measured as a quantitative trait (P=0.02). Analyses limited only to the post-menopausal women showed similar or even stronger results. No other locus among those tested showed any evidence of linkage by either method. The results provided strong evidence that genetic variation at the interleukin-6 locus affects regulation of bone mineral metabolism and confers risk for osteopenia and osteoporosis in adult women.

• 日本医科大学の論文
• 2000-03-25

著者

• HOSOI Takayuki

  Department of Advanced Medicine, National Center for Geriatrics and Gerontology

• Emi Mitsuru

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• NAKAJIMA Toshiaki

  Department of Molecular Biology-Institute of Gerontology, Nippon Medical School

• Saito Yasushi

  千葉大学 臨床遺伝子応用医学

• Emi Mitsuru

  東京都老人医療センター

• HUNT Steven

  Cardiovascular Genetics Research Clinic, University of Utah Heart Science Center

• Nakajima Toshiaki

  Department Of Ischemic Circulatory Physiology University Of Tokyo

• Nakajima T

  Department Of Orthopedic Surgery University Of Occupational And Environmental Health

• Nishimura Taiji

  千葉大学 医学研究院泌尿器科

• Shuin Taro

  Department Of Urology Kouchi Medical University

• Hosoi Takayuki

  Tokyo Metropolitan Geriatric Hospital

• Hosoi Takayuki

  Endocrinology Section

• Hunt Steven

  Cardiovascular Genetics Department Of Internal Medicine Cardiology Division University Of Utah Schoo

• Emi Mitsuru

  Department Of Biochemistry Cancer Institute

• ORIMO HAJIME

  Tokyo Metropolitan Geriatric Medical Centre

• SUZUKI Takao

  Tokyo Metropolitan Institute of Gerontology

• ORIMO Hajime

  Health Science University

• Shiba T

  Department Of Molecular Biology Kitasato University

• OTA Nobutaka

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Orimo H

  Health Science University

• SHIRAI Yasumasa

  Department of Orthopedics, Nippon Medical School

• Orimo Hajime

  Tokyo Metropolitan Geriatric Hospital

• Shiba Tadayoshi

  Department Of Molecular Biology Kitasato University

• Hunt Steven

  Cardiovascular Genetics Department Of Medicine University Of Utah School Of Medicine

• Hosoi Takayuki

  Department Of Internal Medicine Tokyo Metropolitan Geriatric Hospital

• Shuin Taro

  Tokyo Metropolitan Institute Of Gerontology

• Orimo Hajime

  Department Of Geriatrics Faculty Of Medicine University Of Tokyo

• Shirai Yasumasa

  Department Of Clinical Cell Biology Graduate School Of Medicine Chiba University

• Ota Nobutaka

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Nakamura Tetsuro

  Department Of Endocrinology Tokyo Metropolitan Geriatric Hospital

• Orimo Hajime

  General Research Committee For Prevention Of Osteoporosis Ministry Of Health And Welfare Tokyo Metro

• Emi Mitsuru

  Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School

• Nakajima Toshiaki

  Department Of Cardiology Tokyo University

• Emi Mitsuru

  Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School

• Suzuki Takao

  Department Of Surgical Pathology Showa University Fujigaoka Hospital

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