Identification of a 1-Mb Common Region at 16q24.1-24.2 Deleted in Hepatocellular Carcinoma

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概要

• 論文の詳細を見る

• To identify the location of one or more putative tumor suppressor genes that may be involved in hepatocellular carcinoma (HCC), we examined 96 such tumors for their patterns of allelic loss at 21 microsatellite marker loci distributed along chromosome arm 16q. Allelic loss at one or more loci was observed in 58 (60%) of these tumors. Detailed deletion mapping identified a distinct commonly deleted region located within an interval flanked by D165534 and D1653091 at 16q24.1-24.2. By constructing a physical map consisting of a YAC contig across the region, the extent of the deleted region was determined to be less than 1 Mb. Among the tumors for which clinical data were available, allelic loss at 16q24.1-24.2 was more frequent in tumors arising from liver cirrhosis compared to HCCs arising from chronic hepatitis (30/42,71%, vs. 13/33,39%; P=0.0054). Additionally, allelic loss at 16q24.1-24.2 was frequently observed in small tumors and early-stage tumors as well as in tumors of more advanced phenotype.

• 日本医科大学の論文
• 2001-03-25

著者

• Emi Mitsuru

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Nagai Hisaki

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Matsumoto Satoshi

  Department Of Pathology Nara Medical University

• Emi M

  Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School

• TAJIRI Takashi

  Department of Surgery I, Nippon Medical School

• Nagai H

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Nagai Hisaki

  日本医科大学老人病研究所

• Nagai H

  Department Of Surgery Tokyo Women's Medical University Daini Hospital

• Nagai Hisaki

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Tsuruo T

  Division Of Experimental Chemotherapy Cancer Chemotherapy Center Japanese Foundation For Cancer Rese

• Onda Masahiko

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Bando Koichi

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Koyama Masaaki

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Kawamura Naoki

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Tajiri Takashi

  First Department of Surgery, Nippon Medical School

• Onda Masahiko

  First Department of Surgery, Nippon Medical School

• Tajiri T

  Department Of Surgery I Nippon Medical School

• Kawamura N

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Kawamura Naoki

  Department Of Computer Science The University Of Electro-communications:(present Address)tokyo Techn

• Koyama Masaaki

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Emi Mitsuru

  Department Of Biochemistry Cancer Institute

• Nishi Hirofumi

  Cardiovascular Center Kurume University

• Tajiri Takashi

  First Department Of Surgery Nippon Medical School

• Emi Mitsuru

  Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School

• Bando Koichi

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School:first Department Of S

• Bando Koichi

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Onda Masahiko

  First Department Of Surgery Nippon Medical School

• Shimizu Masashi

  Department Of Pathology Nara Medical University

• Bando Kouichi

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Matsumoto Satoshi

  Department Of Neurological Surgery Kobe University School Of Medicine

• Saito Mitsue

  Department Of Breast Surgery Cancer Institute Hospital

• Matsumoto Satoshi

  Department Of Electrical Electronic And Computer Engineering The Kyushu Institute Of Technology

• Matsumoto Satoshi

  Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University

• Matsumoto Satoshi

  Department Of Agricultural Chemistry University Of Tokyo

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