Mapping of a New Target Region of Allelic Loss to a 2-cM Interval at 22q 13.1 in Primary Breast Cancer

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概要

• 論文の詳細を見る

• Allelic losses on chromosome arm 22q are frequently observed in human meningiomas and in carcinomas of the colon, ovary, and breast. Among 140 primary breast cancers we examined for loss of heterozygosity (LOH) at 16 polymorphic loci on the long arm of chromosome 22,56 (40%) showed LOH for at least one locus. Eleven of these tumors had retained heterozygosity for markers proximal to the NF2 locus but showed LOH for markers distal to NF2. Deletion mapping indicated a new common region of deletion, 2-cM in extent, at q13.1 between Interleukin 2 receptor β (IL2RB) and D22S279. Our results raise the possibility that one or more tumor suppressor genes associated with breast cancer may exist at 22q13.1. Comparison of these results with clinicohistological data indicated that allelic losses on 22q tend to occur more frequently in tumors of malignant histological types. Genes Chromosomes Cancer 21 : 108-112,1998.

• 日本医科大学の論文
• 1998-03-25

著者

• Emi Mitsuru

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Sakamoto Goi

  Department of Surgery and Pathology, Cancer Institute Hospital

• Kasumi Fujio

  Department of Surgery and Pathology, Cancer Institute Hospital

• 三木 義男

  癌研ゲノムセンター

• Nakamura Yusuke

  Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of T

• Iida Aritoshi

  東京大学医科学研究所ヒトゲノム解析センター

• Aritoshi Iida

  Laboratory For Pharmacogenetics Snp Research Center The Institute Of Physical And Chemical Research

• Iida A

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Iida Aritoshi

  理化学研究所遺伝子多型研究センター

• Akiyama Fumihiro

  Human Genome Center The Institute Of Medical Science University Of Tokyo

• Yoshimoto M

  The Cancer Institute Of Japanese Foundation For Cancer Research (jfcr)

• Matsumoto-mishima Yuko

  癌研究会癌化学療法センター 臨床研究部

• Yoshimoto Masataka

  Department of Surgery and Pathology, Cancer Institute

• Akiyama Futoshi

  Department of Surgery and Pathology, Cancer Institute

• Fukino K

  Department Of Breast Surgery The Cancer Institute Hospital Of Jfcr

• Kasumi Fujio

  Department Of Breast Surgery Cancer Institute Hospital

• Iida Aritoshi

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Emi Mitsuru

  Department Of Biochemistry Cancer Institute

• KUROSE Keisuke

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Isobe Rie

  Department of Molecular Biology, Institute of Gerontology (ROUKEN), Nippon Medical School

• Kasumi Fujio

  Department Of Breast Surgery The Cancer Institute Hospital Of Jfcr

• Sakamoto Goi

  Department Of Breast Pathology The Cancer Institute Of Japanese Foundation For Cancer Research

• Sakamoto Goi

  Department Of Breast Pathology Cancer Institute

• Kurose Keisuke

  Department Of Obstetrics And Gynecology Nippon Medical School

• Kurose Keisuke

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Iida Aritoshi

  Laboratory For Genotyping Riken Snp Research Center C/o Institute Of Medical Science The University

• Akiyama Futoshi

  Division Of Pathology Cancer Institute Of Japanese Foundation For Cancer Research

• Akiyama Futoshi

  Department Of Breast Pathology Cancer Institute And Hospital Japanese Foundation For Cancer Research

• Iida Aritoshi

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Nakamura Yusuke

  Laboratory For Molecular Medicine Human Genome Center The Institute Of Medical Science University Of

• Iida Aritoshi

  Laboratory For Bone And Joint Diseases Center For Genomic Medicine Riken

• Isobe Rie

  Department Of Molecular Biology Institute Of Gerontology (rouken) Nippon Medical School

• Nakamura Yusuke

  Laboratory Of Molecular Medicine Human Genome Center Institute Of Medical Science University Of Toky

• Nakamura Yusuke

  Laboratory For Genotyping Riken Snp Research Center C/o Riken Yokohama Institute

• Kurose Keisuke

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School:department Of Obstetr

• Yoshimoto Masataka

  Department Of Molecular Diagnosis Cancer Institute Japanese Foundation For Cancer Research

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