Overrepresentation of the EBAG9 Gene at 8q23 Associated with Early-Stage Breast Cancers

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概要

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• EBAG9,an estrogen-responsive gene located at 8q23 was identified in an effort to clone CpG-binding sites. Its product was later found to be identical to RCAS1,a cancer cell-surface antigen implicated in immune escape. We determined the sequence of the complete cDNA and the genomic structure for EBAG9. EBAG9 gene copy number in 21% (27 of 129) primary breast cancers we examined; EBAG9 mRNA was consistently expressed in cancer cell lines. Detailed physical mapping of the 8q arm, including polymorphic markers for EBAG9 and the CMYC loci, revealed allelic gain of either EBAG9,CMYC, or both, in 45% (58 of 129) of the breast cancers we examined. The EBAG9 gene was increased exclusively in 16 of the 27 tumors showing gain at that locus; the other 11 showed gain of a larger chromosomal region containing both EBAG9 and CMYC. Analysis of subsequent series of 144 primary breast cancers for allelic gain at EBAG9 and CMYC locus showed a similar degree of gain at EBAG9,CMYC, or both. When a total of 273 breast cancers from two series were combined and analyzed for clinicopathological correlation, almost all of the tumors with EBAG9 increased but not those with CMYC. Twenty-eight of 29 were T1/T2 stage carcinomas (<5 cm in diameter), whereas one third (21 of 61) of the tumors in which CMYC was increased but EBAG9 was not, were advanced T3-stage tumors (P=0.0012). These data suggest that EBAG9 and CMYC gene are independent targets of gain and that overrepresentation of EBAG9 may play a specific role in early stages of breast carcinogenesis.

• 2002-03-25

著者

• Tsuneizumi Michiko

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Emi Mitsuru

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Nagai Hisaki

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Harada Haruhito

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Sakamoto Goi

  Department of Surgery and Pathology, Cancer Institute Hospital

• Kasumi Fujio

  Department of Surgery and Pathology, Cancer Institute Hospital

• Inoue Satoshi

  Department of Geriatric Medicine, University of Tokyo

• Kazui Teruhisa

  First Department of Surgery, Humamatsu University School of Medicine

• Nakamura Yusuke

  Institute of Medical Science, University of Tokyo

• Emi M

  Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School

• Emi Mitsuru

  東京都老人医療センター

• Nagai H

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Nagai Hisaki

  日本医科大学老人病研究所

• Nagai H

  Department Of Surgery Tokyo Women's Medical University Daini Hospital

• Nagai Hisaki

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Harada Haruhito

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Harada Haruhito

  日本医科大学老人病研究所

• Harada Haruhito

  Division Of Cardiovascular Disease Kurume University Medical Center

• Nagane Yutaka

  Department Of Urology Sanai Hospital

• Nakamura Y

  東京大学医科学研究所ヒトゲノム解析センター ゲノムシークエンス解析分野

• Fukino K

  Department Of Breast Surgery The Cancer Institute Hospital Of Jfcr

• Kasumi Fujio

  Department Of Breast Surgery Cancer Institute Hospital

• Inoue Satoshi

  Department Of Geriatric Medicine The University Of Tokyo

• Emi Mitsuru

  Department Of Biochemistry Cancer Institute

• Nishi Hirofumi

  Nishi Hospital

• Nishi Hirofumi

  Cardiovascular Center Kurume University

• Kazui Teruhisa

  First Department Of Surgery Hamamatsu University School Of Medicine

• Emi Mitsuru

  Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School

• Kasumi Fujio

  Department Of Breast Surgery The Cancer Institute Hospital Of Jfcr

• Sakamoto Goi

  Department Of Breast Pathology The Cancer Institute Of Japanese Foundation For Cancer Research

• Sakamoto Goi

  Department Of Breast Pathology Cancer Institute

• Emi Mitsuru

  Department Of Molecular Biology-institute Of Gerontology Nippon Medical School

• Tsuneizumi Michiko

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Nakamura Yusuke

  Univ. Tokyo Tokyo Jpn

• Emi Mitsuru

  Ddepartment Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Nakamura Yusuke

  Laboratory Of Molecular Medicine Human Genome Center Institute Of Medical Science University Of Toky

• Nakamura Yusuke

  Institute Of Medical Science The University Of Tokyo The Snp Research Center Riken

• Inoue Satoshi

  Department Of Chemistry And Materials Engineering Faculty Of Chemistry Materials And Bioengineering

• Nakamura Yusuke

  Institute Of Medical Science Laboratory Of Molecular Medicine Human Genome Center The University Of Tokyo

• Inoue Satoshi

  Department of Applied Chemistry, Graduate School of Engineering, Osaka University

• Harada Haruhito

  Department of Cardiology, Kurume University Medical Center

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