Fusion of a Novel Gene, ELKS, to RET Due to Translocation t(10;12)(q11;p13) in a Papillary Thyroid Carcinoma
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概要
- 論文の詳細を見る
In papillary thyroid carcinomas, the genes for receptor-type tyrosine kinase, RET or TRKA, are sometimes rearranged, resulting in fusion of its tyrosine kinase domain to 5' portions of several activating genes. In a papillary thyroid carcinoma, we identified a novel gene (ELKS), the 5' portion of which is fused to the RET gene by gene rearrangement due to the translocation t(10; 12)(q11; p13). Subsequent cloning of the ELKS cDNA revealed that ELKS encodes a novel 948 amino acid peptide and is expressed ubiquitously in human tissues. The presence of multiple coiled-coil domains in the ELKS product suggests that the ELKS protein forms dimers. Since the tyrosine kinase of RET is activated by dimerization that occurs when its ligands bind to the receptor, fusion of RET with the 5' dimerization domains of ELKS would activate its cytoplasmic tyrosine kinase constitutively in papillary thyroid carcinomas.
- 日本医科大学の論文
- 2000-03-25
著者
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Emi Mitsuru
Department of Molecular Biology, Institute of Gerontology, Nippon Medical School
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SHIMIZU KAZUO
Department of Surgery, Cardiovascular Surgery, Nippon Medical School
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Emi M
Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School
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Tanaka Shigeo
Department Of Disease Control And Homeostasis Kanazawa University
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Tanaka S
Division Of Thoracic Surgery Department Of Surgery Nippon Medical School
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Yokoyama Shiro
日本医科大学老人病研究所 分子生物学 部門
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Yokoyama Shiro
Department Of Second Surgery Shinshu-university
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NAKATA Tomoko
Department of molecular Biology, Institute of Gerontology, Nippon Medical School
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Emi Mitsuru
Department Of Biochemistry Cancer Institute
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ITO Kouichi
Ito Hospital
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KITAMURA Yutaka
Department of Molecular Biology, Institute of Gerontology, Nippon Medical School
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FUJIMORI Minoru
Department of Surgery, Shinshu University School of Medicine
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Tanaka Shigeo
Department Of Anatomy Nihon University School Of Dentistry At Matsudo
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Yokoyama Shiro
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
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Emi Mitsuru
Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School
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Nakata Tomoko
Department Of Molecular Biology Institute Of Gerontology Nippon Medical School
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Nakata Tomoko
Department Of Bioregulation Institute Of Development And Aging Sciences Nippon Medical School
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Shimizu Kazuo
Department Of Electronics Faculty Of Engineering Ibaraki University
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Ito Kouichi
Surgical Branch Ito Hospital
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Ito Kunihiko
Department Of Surgery Ito Hospital
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Fujimori Minoru
Department Of Second Surgery Shinshu-university
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Fujimori Minoru
Department Of Breast Surgery Tokyo Medical University Ibaraki Medical Center
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Kitamura Yutaka
Department Of Molecular Biology Institute Of Gerontology Nippon Medical School:department Of Second
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Tanaka Shigeo
Division Of Diagnostic Pathology Nippon Medical School Hospital
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Shimizu Kazuo
Department Of Biological Regulation And Regenerative Surgery Graduate School Of Medicine Nippon Medi
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