Localization of a Tumor Suppressor Gene Associated With Progression of Human Prostate Cancer Within a 1.2 Mb Region of 8p22-p21.3

スポンサーリンク

概要

• 論文の詳細を見る

• Human prostate cancers frequently show loss of heterozygosity at loci on the short arm of chromosome 8. In order to take a step toward isolation of the putative tumor suppressor gene(s) on 8p via positional cloning, we performed high-resolution deletion mapping in 46 prostate cancers (stage B, 20 cases; stage C, 8 cases; endocrine therapy-resistant cancer death, 18 cases) using new 12 restriction fragment length polymorphism markers for this chromosomal region. Allelic losses were observed in 25 of the 44 cases (57%) that were informative with at least one locus. Detailed deletion mapping defined a 1.2Mb commonly deleted region at 8p22-p21.3 flanked by markers cMSR-32 and C18-1051. A second region of common deletion was identified between C18-1312 and C18-494 at 8p21-8p11.22,suggesting that at least two tumor suppressor genes associated with prostate cancer are present on chromosome arm 8p. Allelic losses on 8p were observed more frequently in the cancer death cases (14/17,82%) than in early-stage tumors (11/27,40%; P<0.01,Fisher's exact test). In two out of 7 patients for whom DNA was available from metastatic cancers as well as from normal tissues and primary tumors, the primary cancer foci had no detectable abnormality of 8p, but the metastatic tumors showed loss of heterozygosity. These results suggest that inactivation of tumor suppressor genes on 8p plays an important role in the progression of prostate cancer. Genes Chromosom Cancer 13 : 168-174 (1995).

• 日本医科大学の論文
• 1996-03-25

著者

• Emi Mitsuru

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Araki Kazuhiro

  千葉大学フロンティアメディカル工学研究開発センター

• Emi Mitsuru

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• KOMIYA Akira

  Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, Univers

• SUZUKI Hiroyoshi

  Department of Urology, Graduate School of Medicine, Chiba University

• Yatani Ryuichi

  Department of Pathology, Faculty of Medicine, Mie University

• Shimazaki Jun

  Department of Urology, School of Medicine, Chiba University

• Fujiwara Yoshiyuki

  Department of Biochemistry, Cancer Institute

• Nakamura Yusuke

  Department of Biochemistry, Cancer Institute

• Suzuki H

  Department Of Urology Graduate School Of Medicine Chiba University

• Suzuki Hiroyoshi

  千葉大学 大学院医学研究院泌尿器科学

• Komiya A

  Department Of Urology Graduate School Of Medicine And Pharmaceutical Sciences For Research Universit

• Komiya Akira

  富山大学 医学薬学研究部腎泌尿器科学

• Komiya Akira

  Department Of Urology Graduate School Of Medicine And Pharmaceutical Science For Research University

• Komiya Akira

  Department Of Urology Chiba University Graduate School Of Medicine

• Nakamura Y

  Osaka Univ. Medical School Osaka

• Yatani Ryuichi

  Second Department Of Pathology Mie University Faculty Of Medicine

• Yatani Ryuichi

  三重大学 病理学第2

• Yatani Ryuichi

  三重県立志摩病院

• Yatani Ryuichi

  The 2nd Department Of Pathology Mie University School Of Medicine

• Yatani Ryuichi

  Department Of Pathology Mie University School Of Medicine

• Emi Mitsuru

  Department Of Biochemistry Cancer Institute

• Suzuki Hiroyoshi

  Department Of Electronic Engineering Faculty Of Technology Tokyo University Of Agriculture And Techn

• Shimazaki Jun

  Department Of Urology School Of Medicine Chiba University

• Shimazaki Jun

  Department Of Ophthalmology Tokyo Dental College

• Komiya Akira

  Department Of Urology Chiba University School Of Medicine

• Fujiwara Yoshiyuki

  Department Of Biochemistry Cancer Institute

• Shimazaki Jun

  Department Of Ophthalmology School Of Medicine Keio University

• Nakamura Yusuke

  Department Of Biochemistry Cancer Institute

• Nakamura Yasuyuki

  Cancer Medicine And Biophysics Division National Cancer Center Research Institute

• SHIMAZAKI JUN

  Department of Dermatology, School of Medicine, Chiba University

関連論文

• Overrepresentation of the EBAG9 Gene at 8q23 Associated with Early-Stage Breast Cancers
• Down-regulation of members of glycolipid-enriched membrane raft gene family, MAL and BENE, in cervical squamous cell cancers
• Genetic Association of Low-Density Lipoprotein Receptor-Related Protein 2 (LRP2) with Plasma Lipid Levels
• Association of nucleotide variations in the apolipoprotein B48 receptor gene (APOB48R) with hypercholesterolemia
• Hypercholesterolemia associated with splice-junction variation of inter-α-trypsin inhibitor heavy chain 4 (ITIH4) gene
• A promoter SNP (-1323T>C) in G-substrate gene (GSBS) correlates with hypercholesterolemia
• Hypertriglyceridemia associated with amino acid variation Asn985Tyr of the RP1 gene
• G-substrate gene promoter SNP (-1323T>C) modifies plasma total cholesterol and triglyceride phenotype in familial hypercholesterolemia : Intra-familial association study in an eight-generation hyperlipidemic kindred
• Soluble epoxide hydrolase variant (Glu287Arg) modifies plasma total cholesterol and triglyceride phenotype in familial hypercholesterolemia : intrafamilial association study in an eight-generation hyperlipidemic kindred
• Interaction between the LDL-receptor gene bearing a novel mutation and a variant in the apolipoprotein A-II promoter : molecular study in a 1135-member familial hypercholesterolemia kindred
• Characterization of liver-cirrhosis nodules by analysis of gene-expression profiles and patterns of allelic loss
• Common null variant, Arg192Stop, in a G-protein coupled receptor, olfactory receptor 1B1, associated with decreased serum cholinesterase activity
• Three Distinct Commonly Deleted Regions of Chromosome Arm 16q in Human Primary and Metastatic Prostate Cancers
• Localization of a Tumor Suppressor Gene Associated With Progression of Human Prostate Cancer Within a 1.2 Mb Region of 8p22-p21.3
• A 3-Mb Physical Map of the Chromosome Region 8p21.3-p22,Including a 600-kb Region Commonly Deleted in Human Hepatocellular Carcinoma, Colorectal Cancer, and Non-Small Cell Lung Cancer
• Clinical variant of Tangier disease in Japan : mutation of the ABCA1 gene in hypoalphalipoproteinemia with corneal lipidosis
• Allelic Losses of Loci at 3p25.1,8p22,13q12,17p13.3,and 22q13 Correlate with Postoperative Recurrence in Breast Cancer
• Segmental Copy Number Loss of SFMBT1 Gene in Elderly Individuals with Ventriculomegaly: A Community-Based Study
• Genetic mapping of allelic loss on chromosome 6q within heterogeneous prostate carcinoma
• Identification of a 1-Mb Common Region at 16q24.1-24.2 Deleted in Hepatocellular Carcinoma
• Allelic Loss at 1p34,13q12,17p13.3,and 17q21.1 Correlates With Poor Postoperative Prognosis in Breast Cancer
• Identification of a 1-cM Region of Common Deletion on 4q35 Associated With Progression of Hepatocellular Carcinoma
• Correlation of Allelic Loss with Poor Postoperative Survival in Breast Cancer
• PTEN/MMAC1 Mutations in Hepatocellular Carcinomas: Somatic Inactivation of Both Alleles in Tumors
• Frequent Allelic Loss at 6q26-27 in Breast Carcinomas of the Solid-tubular Histologic Type
• Detailed Deletion Mapping of Chromosome Arm 3p in Breast Cancers : A 2-cM Region on 3p 14.3-21.1 and a 5-cM Region on 3p 24.3-25.1 Commonly Deleted in Tumors
• Correlation of Allelic Losses and Clinicopathological Factors in Primary Breast Cancers
• Mapping of a Breast Cancer Tumor Suppressor Gene Locus to a 4-cM Interval on Chromosome 18q21
• Expression profiling to predict postoperative prognosis for estrogen receptor-negative breast cancers by analysis of 25,344 genes on a cDNA microarray
• Up-regulation of transcriptional factor E2F1 in papillary and anaplastic thyroid cancers
• Amplification, up-regulation and over-expression of C3G (CRK SH3 domain-binding guanine nucleotide-releasing factor) in non-small cell lung cancers
• Upregulation and Overexpression of Human X-box Binding Protein 1 (hXBP-1) Gene in Primary Breast Cancers
• Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers
• Ret/PTC3 is the most frequent form of gene rearrangement in papillary thyroid carcinomas in Japan
• Allelic Loss on Chromosome 9q Is Associated with Lymph Node Metastasis of Primary Breast Cancer
• Nucleotide variations in genes encoding plasminogen activator inhibitor-2 and serine proteinase inhibitor B10 associated with prostate cancer
• Association of common missense changes in ELAC2 (HPC2) with prostate cancer in a Japanese case-control series
• Genomic Structure and Mapping of Human Orphan Receptor LXR Alpha : Upregulation of LXRa mRNA During Monocyte to Macrophage Differentiation
• Genetic Association between Aldehyde Dehydrogenase 2 (ALDH2) Variation and High-Density Lipoprotein Cholesterol (HDL-C) Among Non-Drinkers in Two Large Population Samples in Japan
• Association of an intronic haplotype of the LIPC gene with hyperalphalipoproteinemia in two independent populations
• Functional impairment of two novel mutations detected in lipoprotein-associated phospholipase A2 (Lp-PLA2) deficiency patients
• Correlation of Allelic Losses and Clinicopathological Factors in 504 Primary Breast Cancers
• Association of Allelic Losses at 3p25.1, 13q12, or 17p13.3 with Poor Prognosis in Breast Cancers with Lymph Node Metastasis
• Allelic Loss at 1p34-36 Predicts Poor Prognosis in Node-negative Breast Cancer
• DNA alterations during multi-step development of human hepatocellular carcinomas revealed by laser capture microdissection
• Genomic structure of the gene encoding human 3-hydroxy-3-methyl-glutaryl coenzyme A reductase : comparison of exon/intron organization of sterol-sensing domains among four related genes
• Genomic structure and chromosomal mapping of the human sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) gene
• Differentially Regulated Genes as Putative Targets of Amplifications at 20q in Ovarian Cancers
• Definition of a 1-Mb homozygous deletion at 9q32-q33 in a human bladder-cancer cell line
• Two Target Regions of Allelic Loss on Chromosome 9 in Urinary-bladder Cancer
• Mapping of a New Target Region of Allelic Loss to a 6-cM Interval at 21q21 in Primary Breast Cancers
• Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas
• Molecular cloning, tissue expression, and chromosomal assignment of a novel gene encoding a subunit of the human signal-recognition particle
• Association of single nucleotide polymorphisms in the promoter region of the pro-opiomelanocortin gene (POMC) with low bone mineral density in adult women
• Association of a single-nucleotide polymorphism in the promoter region of leukemia inhibitory factor receptor gene with low bone mineral density in adult women
• Linkage disequilibrium and haplotype analysis among four novel single-nucleotide polymorphisms in the human leukemia inhibitory factor (LIF) gene
• Association of a single-nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 gene with bone mineral density
• Association of genetic variation of the RIL gene, encoding a PDZ-LIM domain protein and localized in 5q31.1, with low bone mineral density in adult Japanese women
• Association of natural tooth loss with genetic variation at the human matrix Gla protein locus in elderly women
• Association of the -381T/C promoter variation of the brain natriuretic peptide gene with low bone-mineral density and rapid postmenopausal bone loss
• Thirteen single-nucleotide polymorphisms in the human osteopontin gene identified by sequencing of the entire gene in Japanese individuals
• Linkage disequilibrium and haplotype analysis among ten single-nucleotide polymorphisms of interleukin 11 identified by sequencing of the gene
• Genomic structure and chromosomal mapping of the human Site-1 protease (S1P) gene
• Isolation and radiation hybrid mapping of a highly polymorphic CA repeat sequence at the SREBP cleavage-activating protein (SCAP) locus
• Two Distinct Commonly Deleted Regions on Chromosome 13q Suggest Involvement of BRCA2 and Retinoblastoma Genes in Sporadic Breast Carcinomas
• PRLTS Gene Alterations in Human Prostate Cancer
• A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density
• Association of bone mineral density with a dinucleotide repeat polymorphism at the calcitonin (CT) locus
• Linkage of interleukin 6 locus to human osteopenia by sibling pair analysis
• Association of bone mineral density with polymorphism of the human matrix Gla protein locus in elderly women
• The important role for βVLDLs binding at the fourth cysteine of first ligand-binding domain in the low-density lipoprotein receptor
• Down-regulation in Multiple Human Cancers of a Novel Gene, DMHC, from 17q25.1 That Encodes an Integral Membrane Protein
• Identification of DMC1, a novel gene in the TOC region on 17q25.1 that shows loss of expression in multiple human cancers
• Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma
• Eight novel mutations and functional impairments of the LDL receptor in familial hypercholesterolemia in the north of Japa
• Apolipoprotein H Variant Modifies Plasma Triglyceride Phenotype in Familial Hypercholesterolemia : A Molecular Study in an Eight-generation Hyperlipidemic Family
• Three Aberrant Splicing Variants of the HMGIC Gene Transcribed in Uterine Leiomyomas
• Frequent Allelic Loss at 7p14-15 Associated with Aggressive Histologic Types of Breast Cancer
• Mapping of a New Target Region of Allelic Loss to a 2-cM Interval at 22q 13.1 in Primary Breast Cancer
• Novel single nucleotide polymorphisms of the human nuclear factor kappa-B 2 gene identified by sequencing the entire gene
• Novel single nucleotide polymorphisms of the human colony-stimulating factor 2 (CSF2) gene identified by sequencing the entire gene
• Five novel single-nucleotide polymorphisms of human interferon gamma identified by sequencing the entire gene
• Five familial hypercholesterolemic kindreds in Japan with novel mutations of the LDL receptor gene
• Familial Hypercholesterolemia with Cholesteryl Ester Traansfer Protein Deficiency
• Association of estrogen receptor β (ESR2) gene polymorphism with blood pressure
• Isolation and radiation hybrid mapping of a highly polymorphic CA repeat sequence at the human nuclear factor kappa-beta subunit 1 (NFKB1) locus
• Fusion of a Novel Gene, ELKS, to RET Due to Translocation t(10;12)(q11;p13) in a Papillary Thyroid Carcinoma
• Co-segregation of elevated LDL with a novel mutation (D92K) of the LDL receptor in a kindred with multiple lipoprotein abnormalities
• A novel LDLR mutation, H190Y, in a Utah kindred with familial Hypercholesterolemia
• Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes : genomic structure and seven polymorphisms of the FAP-1 gene
• Genomic structure and eight novel exonic polymorphisms of the human N-cadherin gene
• Allelic Loss on Chromosome 1p Is Associated with Progression and Lymph Node Metastasis of Primary Breast Carcinoma
• Overestimated frequency of a possible emphysema-susceptibility allele when microsomal epoxide hydrolase is genotyped by the conventional polymerase chain reaction-based method
• Association of diffuse panbronchiolitis with microsatellite polymorphism of the human interleukin 8 (IL-8) gene
• The c-Jun NH_2-terminal kinase3 (JNK3) gene : genomic structure, chromosomal assignment, and loss of expression in brain tumors
• Nine novel single-nucleotide polymorphisms in the integrin β4 (ITGB4) gene in the Japanese population
• Linkage disequilibrium and haplotype analysis among eight novel single-nucleotide polymorphisms in the human tissue-type plasminogen activator (t-PA) gene
• Human calcitonin receptor-like receptor for adrenomedullin : genomic structure, eight single-nucleotide polymorphisms, and haplotype analysis
• Association between single nucleotide polymorphisms in the hMSH3 gene and sporadic colon cancer with microsatellite instability
• Frameshift Mutations and a Length Polymorphism in the hMSH3 Gene and the Spectrum of Microsatellite Instability in Sporadic Colon Cancer

もっと見る 閉じる

スポンサーリンク