Allelic Losses of Loci at 3p25.1,8p22,13q12,17p13.3,and 22q13 Correlate with Postoperative Recurrence in Breast Cancer

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概要

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• We previously defined 18 chromosomal regions in which frequent allelic losses were observed in breast cancers (T. Sato et al., Cancer Res., 50 : 7184-7189,1990; Y. Harada et al., Cancer (Phila.), 74 : 2281-2286,1994; I. Ito et al., Br. J. Cancer, 71 : 438-441,1995; K. Tsukamoto et al., Cancer (Phila.), 78 : 1929-1934,1996; S. Matsumoto et al., Genes Chromosomes Cancer, 20 : 268-274,1997; T. Yokota et al., Jpn. J. Cancer Res., 88 : 959-964,1997; K. Tsukamoto et al., Cancer (Phila.), 82 : 317-322,1998; A. Iida et al., Genes Chromosomes Cancer, 21 : 108-112,1998; K. Fukino et al., Genes Chromosomes Cancer, 24 : 345-350,1999; T. Yokota et al., Cancer (Phila.), 85 : 447-452,1999; Y. Utada et al., Jpn. J. Cancer Res., 91 : 293-300,2000). To identify specific allelic losses that might correlate with postoperative recurrence, we examined tumors from a cohort of 504 breast cancer patients, who were followed clinically for 5 years postoperatively, for allelic losses of 18 microsatellite markers. Patients whose tumors had lost an allele at 3p25.1,8p22,13q12,17p13.3,or 22q13 had significantly higher risks of recurrence than those whose tumors retained both alleles at those loci; at 3p25.1,the 5-year recurrence rate was 27% among patients with losses versus 18% with retention (P=0.0131); at 8p22,27% versus 14% (P=0.0129); at 13q12,28% versus 15% (P=0.0109); at 17p13.3,27% versus 20% (P=0.0482); and at 22q13,29% versus 20% (P=0.0477). These data indicate that loss of heterozygosity at any one of these five specific loci is a significant predictor of postoperative recurrence among patients who have undergone surgery for breast cancer. These allelic losses can serve as negative prognostic indicators to guide postoperative management of patients.

• 日本医科大学の論文
• 2002-03-25

著者

• Tsuneizumi Michiko

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Emi Mitsuru

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Sakamoto Goi

  Department of Surgery and Pathology, Cancer Institute Hospital

• Kasumi Fujio

  Department of Surgery and Pathology, Cancer Institute Hospital

• 梶原 哲郎

  Tochigi Cancer Center Hospital

• 梶原 哲郎

  東京女子医科大学第二病院外科

• 三木 義男

  癌研ゲノムセンター

• Katagiri Toyomasa

  京都大学 医学部外科学

• Katagiri T

  Univ. Tokyo Tokyo Jpn

• Emi M

  Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School

• Nakamura Yusuke

  Human genome center

• Akiyama Fumihiro

  Human Genome Center The Institute Of Medical Science University Of Tokyo

• Nagane Yutaka

  Department Of Urology Sanai Hospital

• Kajiwara Tetsuro

  Tochigi Cancer Center Hospital

• Kodama Tetsuro

  栃木県立がんセンター研究所 がん遺伝子研究室

• Kasugai Tsutomu

  東京大学医科学研究所ヒトゲノム解析センター 分子医学

• HAGA Shunsuke

  Department of Surgery, Tokyo Women's Medical University Daini Hospital.

• UTADA Yoshihito

  Department of Surgery, Tokyo Women's Medical University Daini Hospital.

• HIRANO Akira

  Department of Surgery, Tokyo Women's Medical University Daini Hospital.

• KAJIWARA Tetsuro

  Department of Surgery, Tokyo Women's Medical University Daini Hospital.

• Yoshimoto M

  The Cancer Institute Of Japanese Foundation For Cancer Research (jfcr)

• Matsumoto-mishima Yuko

  癌研究会癌化学療法センター 臨床研究部

• Yoshimoto Masataka

  Department of Surgery and Pathology, Cancer Institute

• Akiyama Futoshi

  Department of Surgery and Pathology, Cancer Institute

• Nakamura Y

  東京大学医科学研究所ヒトゲノム解析センター ゲノムシークエンス解析分野

• Fukino K

  Department Of Breast Surgery The Cancer Institute Hospital Of Jfcr

• Kasumi Fujio

  Department Of Breast Surgery Cancer Institute Hospital

• Emi Mitsuru

  Department Of Biochemistry Cancer Institute

• Haga Shunsuke

  Department Of Surgery Tokyo Women's Medical University Daini Hospital

• Emi Mitsuru

  Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School

• Kasumi Fujio

  Department Of Breast Surgery The Cancer Institute Hospital Of Jfcr

• Sakamoto Goi

  Department Of Breast Pathology The Cancer Institute Of Japanese Foundation For Cancer Research

• Sakamoto Goi

  Department Of Breast Pathology Cancer Institute

• Utada Yoshihito

  Department Of Surgery Tokyo Women's Medical University Daini Hospital

• Kajiwara Tetsuro

  Department Of Surgery Tokyo Women's Medical College Daini Hospital

• Hirano Akira

  Division Of Thoracic Surgery Department Of Surgery Nippon Medical School

• Katagiri T

  Laboratory Of Molecular Medicine Human Genome Center Institute Of Medical Science University Of Toky

• Emi Mitsuru

  Department Of Molecular Biology-institute Of Gerontology Nippon Medical School

• Hirano Akira

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Akiyama Futoshi

  Division Of Pathology Cancer Institute Of Japanese Foundation For Cancer Research

• Akiyama Futoshi

  Department Of Breast Pathology Cancer Institute And Hospital Japanese Foundation For Cancer Research

• Tsuneizumi Michiko

  Department Of Molecular Biology Institute Of Gerontology Nippon Medical School

• Nakamura Yusuke

  Univ. Tokyo Tokyo Jpn

• Hirano Akira

  Department Of Chemistry And Materials Science Tokyo Institute Of Technology

• Nakamura Yusuke

  Laboratory Of Molecular Medicine Human Genome Center Institute Of Medical Science University Of Toky

• Harada Akima

  Division Of Thoracic Surgery Department Of Surgery Nippon Medical School

• Yoshimoto Masataka

  Department Of Molecular Diagnosis Cancer Institute Japanese Foundation For Cancer Research

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