A 3-Mb Physical Map of the Chromosome Region 8p21.3-p22,Including a 600-kb Region Commonly Deleted in Human Hepatocellular Carcinoma, Colorectal Cancer, and Non-Small Cell Lung Cancer
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概要
- 論文の詳細を見る
To isolate a putative tumor suppressor gene (s), we have constructed a physical map and a detailed deletion map of chromosome region 8p21.3-p22,where loss of heterozygosity (LOH) has been frequently seen in human hepatocellular carcinomas (HCC), colorectal cancers (CRC), and non-small cell lung cancers (NSCLC). The smallest commonly deleted region at 8p21.3-p22 in HCC and CRC was between the loci defined by C18-245 and C18-2644; in NSCLC, a region between C18-1051 and C18-2644 was commonly deleted. A contiguous physical map of 12 cosmid markers in the 8p21.3-p22 region was constructed by means of multi-color fluorescence in situ hybridization (FISH) and pulsed-field gel electrophoresis (PFGE). On the basis of this physical map, which spans roughly 3.1 Mb, the estimated sizes of the commonly deleted regions were at most 1.2 Mb in HCC and CRC and 0.6 Mb in NSCLC. As four of the 12 physically ordered markers are located within the 0.6 Mb region commonly deleted in all three tumor types, nearly one fourth to one fifth of the target region has already been covered with cosmid inserts. Genes Chrom Cancer 10 : 7-14 (1994).
- 日本医科大学の論文
- 1995-03-25
著者
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Emi Mitsuru
Department of Molecular Biology, Institute of Gerontology, Nippon Medical School
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Emi Mitsuru
Department Of Molecular Biology Institute Of Gerontology Nippon Medical School
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Fujiwara Yoshiyuki
Department of Biochemistry, Cancer Institute
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Nakamura Yusuke
Department of Biochemistry, Cancer Institute
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Ohata Hiroyuki
Departments of Biochemistry, Cancer Institute
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Okui Keiko
Departments of Biochemistry, Cancer Institute
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Koyama Kumiko
Departments of Biochemistry, Cancer Institute
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Tsuchiya Eiju
Departments of Pathology, Cancer Institute
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Nakajima Toshifusa
Departments of Surgery, Cancer Institute
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Monden Morito
Second Department of Surgery, Osaka University Medical School
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Mori Takesada
Second Department of Surgery, Osaka University Medical School
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Kurimasa Akihito
Department of Molecular and Cell Genetics, School of Life Science, Faculty of Medicine, Tottori Univ
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Oshimura Mitsuo
Department of Molecular and Cell Genetics, School of Life Science, Faculty of Medicine, Tottori Univ
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Nakamura Y
Osaka Univ. Medical School Osaka
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Emi Mitsuru
Department Of Biochemistry Cancer Institute
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Oshimura Mitsuo
Department Of Biomedical Science Graduate School Of Medical Science Tottori University
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Mori Takesada
Second Department Of Surgery Osaka University Medical School
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KOYAMA Kumiko
Division of Clinical Genetics, Biomedical Research Center
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Oshimura Mitsuo
Department Of Molecular And Cell Genetics School Of Life Science Faculty Of Medicine Tottori Univers
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Monden Morito
Second Department Of Surgery Osaka University Medical School
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Monden Morito
Second Department Of Sugery Osaka University Medical School
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Tsuchiya Eiju
Department Of Pathology Saitama Cancer Center
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Tsuchiya Eiju
Departments Of Pathology Cancer Institute
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Nakajima Toshifusa
Departments Of Surgery Cancer Institute
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Okui Keiko
Departments Of Biochemistry Cancer Institute
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Ohata Hiroyuki
Departments Of Biochemistry Cancer Institute
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Fujiwara Yoshiyuki
Department Of Biochemistry Cancer Institute
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Kurimasa Akihito
Department Of Molecular And Cell Genetics School Of Life Science Faculty Of Medicine Tottori Univers
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Nakamura Yusuke
Department Of Biochemistry Cancer Institute
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Nakamura Yasuyuki
Cancer Medicine And Biophysics Division National Cancer Center Research Institute
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