ASSOCIATION OF ESTROGEN RECEPTOR DINUCLEOTIDE REPEAT POLYMORPHISM WITH OSTEOPOROSIS

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概要

• 論文の詳細を見る

• We investigated the association between dinucleotide (thymine-adenine) repeat polymorphism lying upstream of human estrogen receptor (ER) gene and bone mineral density (BMD) as well as biochemical markers for bone metabolism in 144 healthy postmenopausal Japanese women. The genotype was classified into 'A' through 'R' according to the number of the repeats, from 10 to 27. BMD was expressed in Z score (a deviation from the weight-adjusted average BMD of each age using the standard deviation as a unit). The people having genotype C (12 repeats of thymine-adenine) allele (n=15) had significantly lower Z score of spine BMD (mean±SD; -1.11±1.3vs. -0.06±1.2; p<0.01) and of total body BMD (-0.58±1.0vs. 0.31±0.9; p<0.01) than those without this genotype (n=129). They also had significantly higher levels of serum intact osteocalcin, urinary pyridinoline, and urinary deoxypyridinoline. These results suggest that genetic variation at the ER locus may be associated with some determinants for BMD and bone metabolism in postmenopausal women.

• 日本医科大学の論文
• 1996-03-25

著者

• HOSOI Takayuki

  Department of Advanced Medicine, National Center for Geriatrics and Gerontology

• Emi Mitsuru

  東京都老人医療センター

• SHIRAKI Masataka

  Research Institute and Practice for Involutional Diseases

• Inoue S

  Department Of Geriatric Medicine The University Of Tokyo

• Inoue Satoshi

  Department Of Geriatric Medicine The University Of Tokyo

• Hosoi Takayuki

  Department Of Advanced Medicine National Center For Geriatrics And Gerontology

• ORIMO Hajime

  Health Science University

• Ouchi Yasuyoshi

  Department Of Geriatric Medicine Faculty Of Medicine The University Of Tokyo

• Shintani Masafumi

  Department Of Obstetrics And Gynecology Narakenritsu Mimuro Hospital

• Hosoi Takayuki

  Department Of Internal Medicine Tokyo Metropolitan Geriatric Hospital

• Sano Michio

  Department Of Geriatrics Faculty Of Medicine University Of Tokyo

• Orimo Hajime

  Department Of Endocrinology Tokyo Metropolitan Geriatric Medical Center

• Orimo Hajime

  Department Of Geriatrics Faculty Of Medicine University Of Tokyo

• Orimo Hajime

  General Research Committee For Prevention Of Osteoporosis Ministry Of Health And Welfare Tokyo Metro

• Emi Mitsuru

  Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School

• Emi Mitsuru

  Institute of Gerontology, Nippon Medical School

• Shiraki Masataka

  Department Of Internal Medicine Research Institute And Practice For Involutional Diseases

• Shiraki Masataka

  Research Institute And Practice For Involutional Disease

• Inoue Satoshi

  Department Of Chemistry And Materials Engineering Faculty Of Chemistry Materials And Bioengineering

• Ouchi Yasuyoshi

  Department Of Biostatistics Epidemiology And Preventive Health Sciences The University Of Tokyo

• ORIMO HAJIME

  Department of Endocrinology and Metabolism, Tokyo Metropolitan Geriatric Hospital

• Inoue Satoshi

  Department of Applied Chemistry, Graduate School of Engineering, Osaka University

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