Association of a Sequence Variation in the Gene Encoding Adiponectin Receptor 1 (ADIPOR1) with Body Mass Index in the Japanese Population
スポンサーリンク
概要
- 論文の詳細を見る
Background: Adiponectin is a circulating peptide present in adipose tissue. It mediates its insulin-sensitizing and anti-atherogenic effects on target tissues via 2 receptors—adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2). Recent studies have reported that ADIPOR1 deficiency in mice results in increased body weight and obesity. In the present study, we examined the association between a single nucleotide polymorphism (SNP) in the 5´ flanking region of the ADIPOR1 gene and body mass index (BMI) in the Japanese population.Methods: Association of an SNP (rs4989513) with the BMI was examined in 774 postmenopausal Japanese women.Results: Rs4989513 SNP was significantly associated with the BMI (P = 0.0412).Conclusion: Genetic variation at the ADIPOR1 gene locus is associated with BMI, suggesting that the ADIPOR1 gene is involved in the development of obesity.
- 一般社団法人 日本抗加齢医学会の論文
著者
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Inoue Satoshi
Department of Geriatric Medicine, University of Tokyo
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OUCHI Yasuyoshi
Department of Geriatric Medicine, University of Tokyo
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Ouchi Y
University Of Tokyo
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URANO Tomohiko
Department of Geriatric Medicine, Graduate School of Medicine University of Tokyo
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SHIRAKI Masataka
Research Institute and Practice for Involutional Diseases
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Yamaga Ryonosuke
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo
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Sasaki Noriko
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo
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Ouchi Y
Department Of Geriatric Medicine Graduate School Of Medicine University Of Tokyo
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Urano Tomohiko
Department Of Geriatric Medicine Faculty Of Medicine The University Of Tokyo
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Inoue S
Department Of Geriatric Medicine The University Of Tokyo
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Sasaki Noriko
Department Of Geriatric Medicine Graduate School Of Medicine The University Of Tokyo
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Shiraki Masataka
Research Institute And Practice For Involutional Disease
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Ouchi Yasuyoshi
Department Of Biostatistics Epidemiology And Preventive Health Sciences The University Of Tokyo
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OUCHI Yasuyoshi
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo
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Inoue Satoshi
Department of Applied Chemistry, Graduate School of Engineering, Osaka University
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