Inhibition of Listeriolysin O-Induced Hemolysis by Bovine Lactoferrin
スポンサーリンク
概要
- 論文の詳細を見る
Lactoferrin (LFR) plays an important role in the anti-microbial defense through iron binding, lipopolysaccharide binding and immunomodulation. In this study, we demonstrate that bovine LFR specifically inhibits the hemolytic activity of listeriolysin O (LLO) produced by Listeria monocytogenes. The hemolytic activity of LLO was completely inhibited in the presence of bovine LFR that was highly purified on two cation-exchange columns, whereas that of streptolysin O or perfringolysin O was not inhibited at all. A rabbit anti-LFR antibody canceled this inhibitory activity of bovine LFR. Although human transferrin exhibits 62% amino acid identity with bovine LFR, human apo-transferrin could not inhibit LLO-induced hemolysis. An increase in the concentration of FeCl_3 or the Fe^<3+>-saturation of bovine LFR, however, slightly reduced its inhibition of the hemolysis.The inhibitory activity of bovine LFR was dependent on pH, since it was observed under neutral and alkali conditions, but not under acidic conditions. These results suggest that the inhibition of LLO-induced hemolysis by bovine LFR is influenced by pH and iron ions, both of which may lead to conformational changes of LFR.
- 公益社団法人日本薬学会の論文
- 1999-11-15
著者
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Inoue Satoshi
Department of Geriatric Medicine, University of Tokyo
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Amano Fumio
Department Of Biochemistry And Cell Biology National Institute Of Infectious Diseases
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Inoue Satoshi
Department Of Geriatric Medicine The University Of Tokyo
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MORIISHI Kohji
Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University
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Moriishi K
Department Of Veterinary Science National Institute Of Infectious Diseases
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Moriishi Kohji
Department Of Molecular Virology Research Institute For Microbial Diseases Osaka University
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KOURA Minako
Department of Veterinary Science, National Institute of Infectious Diseases
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Koura M
Department Of Veterinary Science National Institute Of Infectious Diseases
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Koura Minako
Department Of Veterinary Science National Institute Of Infectious Diseases
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Amano Fumio
Department Of Biochemistry And Cell Biology National Institute Of Infectious Disease
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Amano Fumio
Department Of Biochemistry And Cell Biology National Institute Of Health
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Inoue Satoshi
Department Of Chemistry And Materials Engineering Faculty Of Chemistry Materials And Bioengineering
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Inoue Satoshi
Department of Applied Chemistry, Graduate School of Engineering, Osaka University
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