Pathological and Microbiological Studies of Japanese Hare (Lepus brachyurus angustidens) Naturally Infected with Francisella tularensis subsp. holarctica
スポンサーリンク
概要
- 論文の詳細を見る
An adult male hare (Lepus brachyurus angustidens) was discovered in a moribund condition in the bush in the mountains of Aomori prefecture in Japan. Upon gross inspection, many ticks were found on the neck and the external ear regions, and more than half the ticks contained blood in the intestine. The skin around the tick bite wounds was alopecic and mildly thickened. At necropsy, enlargement of the cervical lymph nodes and spleen were observed. Histologically, acute necrotizing splenitis, lymphadenitis, hepatitis, pneumonia, myelitis, adrenalitis, and encephalitis with bacterial organisms were observed. The cutaneous lesions were chronic and cysts had formed in the areas marked by tick bites. Immunohistochemically, the organisms in the skin, liver, spleen, lymph nodes, lungs, adrenal glands, brain, bone marrow, and ticks were positive for F. tularensis antigen. Microbiological and polymerase chain reaction results were consistent with F. tularensis subsp. holarctica. Because the cutaneous lesions were more chronic than those in the visceral organs and F. tularensis was detected in the ticks, we inferred that F. tularensis was transmitted to the hare via tick bites.
著者
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Chun-ho Park
Department Of Veterinary Pathology Faculty Of Veterinary Medicine And Animal Sciences Kitasato Unive
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Park Chun-ho
Department Of Comparative Pathology Graduate School Of Veterinary Medicine Hokkaido University
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Inoue Satoshi
Department Of Geriatric Medicine The University Of Tokyo
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Oyamada Toshifumi
Department Of Veterinary Pathology Faculty Of Veterinary Medicine And Animal Sciences Kitasato Unive
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Fujita Osamu
Department Of Physics Aoyama-gakuin University
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Sato Hisaaki
Department Of Hygiene And Microbiology Faculty Of Veterinary Medicine Hokkaido University
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Hotta Akitoyo
Department Of Veterinary Microbiology Faculty Of Agriculture Gifu University
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KOJIMA Daisuke
Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University
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Kudo Noboru
Department Of Materials Engineering And Applied Chemistry Mining College Akita University
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TANABAYASHI Kiyoshi
Department of Veterinary Science, National Institute of Infectious Diseases
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HATAI Hitoshi
Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University
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NAKANISHI Ataru
Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University
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SHINDO Junji
Department of Wildlife Science, School of Veterinary Medicine, Kitasato University
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Tanabayashi Kiyoshi
Department Of Veterinary Science National Institute Of Infectious Diseases
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Kojima Daisuke
Department Of Biophysics And Biochemistry Graduate School Of Science The University Of Tokyo
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Fujita Osamu
Department Of Mechanical And Space Engineering Hokkaido University
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Inoue Satoshi
Department Of Chemistry And Materials Engineering Faculty Of Chemistry Materials And Bioengineering
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Park Chun‐ho
Kitasato Univ. Aomori
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Fujita Osamu
Department of Bioresources Science and Technology, Graduate School of Biosphere Science, Hiroshima University
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Inoue Satoshi
Department of Applied Chemistry, Graduate School of Engineering, Osaka University
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Oyamada Toshifumi
Department of Veterinary Pahtology, School of Veterinary Medicine and Animal Sciences, Kitasato University
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