Histopathological, Immunopathological and Electron Microscopic Studies on Pig Liver Inoculated with Pasteurella multocida Dermonecrotic Toxin
スポンサーリンク
概要
- 論文の詳細を見る
Dermonecrotic toxin (DNT) produced by Pasteurella multocida was purified by anion-exchange chromatography, gel filtration, and high-performance liquid chromatography. Pigs were given an intramuscular injection of P.multocida dermonecrotic toxin (Pm-DNA), which produced necrotic lesions of the liver. Liver sections were taken at intervals of 2, 12, and 24 hours after Pm-DNA injection. We examined the sections histopathologically, immunopathologically, and electron microscopically. The earliest alterations observed were loss of glycogen from hepatocytes, which became more severe during later intervals, vacuolation and single-cell necrosis of hepatocytes, as well as desquamation and fragmentation of the sinusoidal endothelium. The vacuoles subsequently increased in quantity and size with the passage of time and found to contain homogeneous fine material and/or fibrillar material. These materials were thought to be fibrin and blood serum. The vacuoles penetrated the cytoplasm of the hepatocytes. We considered that liver necrosis caused by Pm-DNT probably resulted from the principal effects of vascular injury, although the membrane of the hepatocytes was more or less damaged by the toxin.
- 日本毒性病理学会の論文
- 1998-06-01
著者
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YOSHIKAWA Takashi
Department of Aerospace Engineering, University of Tokyo
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YOSHIKAWA Hiroyasu
Department of Veterinary Pathology, School of Veterinary Medicine and Animal Science, Kitasato Unive
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OYAMADA Toshifumi
Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University
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Yoshikawa Hiroyasu
Depatment Of Medicine And Bioregulatory Science Graduate School Of Medical Sciences Kyushu Universit
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Oyamada Toshifumi
Department Of Veterinary Pathology School Of Veterinary Medicine And Animal Sciences Kitasato Univer
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Oyamada Toshifumi
Department Of Veterinary Pathology Faculty Of Veterinary Medicine And Animal Sciences Kitasato Unive
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Yoshikawa Hiroyasu
Department Of Veterinary Pathology School Of Veterinary Medicine And Animal Sciences Kitasato Univer
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Yoshikawa Hiroyasu
Department Of Urology Showa University Fujigaoka Hospital
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Yoshikawa Takashi
Department Of Veterinary Pathology School Of Veterinary Medicine And Animal Sciences Kitasato Univer
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Ike Kazunori
Research Center For Veterinary Science Of The Kitasato Institute
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黒滝 哲郎
Research Center for Veterinary Science of The Kitasato Institute
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ONUMA Hitoshi
Japanese Red Cross Blood Center, Saitama Prefecture
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ARAI Yasuko
Research Center for Veterinary Science of The Kitasato Institute
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KUME Katsumi
Research Center for Veterinary Science of The Kitasato Institute
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Onuma Hitoshi
Japanese Red Cross Blood Center Saitama Prefecture
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Yamaguchi Hiroya
Department Of Veterinary Pathology School Of Veterinary Medicine And Animal Sciences Kitasato Univer
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Yoshikawa Hiroyasu
Department Of Electronics Graduate School Of Engineering Tohoku University
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Oyamada Toshifumi
Department of Veterinary Pahtology, School of Veterinary Medicine and Animal Sciences, Kitasato University
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KUME Katsumi
Research Center for Biologicals, The Kitasato Institute
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