Effects of Mosapride Citrate, 5-HT_4 Receptor Agonist, on Colonic Motility in Conscious Guinea Pigs
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概要
- 論文の詳細を見る
It is known that 5-HT4 receptors in the colon of guinea pigs show a distribution similar to that in humans. Thus, we examined the effects of mosapride citrate (mosapride) and cisapride, two 5-HT4-receptor agonists, on colonic motility in conscious guinea pigs implanted with force transducers. Mosapride and cisapride administered intragastrically at doses of 3 – 30 mg/kg significantly enhanced the colonic motility. The enhancing effect of mosapride was antagonized by atropine or GR113808, a 5-HT4-receptor antagonist, but not by methysergide, a 5-HT1- and 5-HT2-receptor antagonist; ondansetron, a 5-HT3-receptor antagonist; or CP-99994, a tachykinin NK1-receptor antagonist. In vitro receptor autoradiography showed that mosapride and cisapride inhibit the specific binding of [125I]-SB207710, a selective radioligand of 5-HT4 receptors, in the colon of guinea pigs. These results suggest that mosapride enhances colonic motility through the 5-HT4-receptor activation in guinea pigs and may be useful for treating constipation in patients with colonic motility dysfunction.
- 社団法人 日本薬理学会の論文
- 2002-12-01
著者
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YOSHIKAWA Takashi
Department of Aerospace Engineering, University of Tokyo
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Nagai Ryuji
Department Of R&d Group Of Biocybernetics Dainippon Pharmaceutical Co. Ltd.
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Nagai Ryuji
Department Of Biochemistry Kumamoto University School Of Medicine
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Yoshikawa T
Department Of Pharmacology I Discovery Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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INUI Atsuko
Department of Safety Pharmacology, Developmental Research Laboratories, Dainippon Pharmaceutical Co.
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YOSHIDA Naoyuki
Department of Pharmacology I, Discovery Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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ITO Tsugutaka
Department of Safety Pharmacology, Developmental Research Laboratories, Dainippon Pharmaceutical Co.
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Inui Atsuko
Department Of Safety Pharmacology Developmental Research Laboratories Dainippon Pharmaceutical Co. L
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Ito Tsugutaka
Department Of Safety Pharmacology Developmental Research Laboratories Dainippon Pharmaceutical Co. L
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Yoshida N
Department Of Pharmacology I Discovery Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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Yoshida Naoyuki
Department Of Orthopedic Surgery The University Of Tokushima
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Yoshida Naoyuki
Department Of Applied Biology Kyoto Institute Of Technology
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ITO Tsugutaka
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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