Acute EEG changes in rats by brainstem ischemia and its dopaminergic involvement.
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概要
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An acute animal model with irreversible ischemia in the pons (Pons Ischemic Rat, PIR) was developed by two placed occlusions of the basilar artery. PIR showed decerebrate syndromes. Electroencephalograms (EEGs) in d-tubocurarine-immobilized PIR showed inclusion of obviously higher amplitude slower waves in the cortex but similar θ waves in the hippocampus, as compared with those in intact rats. Spontaneous cortical EEGs in PIR were desynchronized by pinching of hind limbs. From the frequency analysis, it was found that this cortical EEG alterations were composed of the decrease of β<SUB>2</SUB> band relative power and the increase of δ-θ<SUB>2</SUB> bands. Haloperidol, at the dose without effect on EEG in intact rats, dose-relatedly decreased the cortical β<SUB>2</SUB> band in PIR, and the potency was 100 times stronger than that in intact rats. On the other hand, the potency of atropine on the cortical β<SUB>2</SUB> band was almost the same in both preparations. Apomorphine, thyrotropin-releasing hormone (TRH), methamphetamine, physostigmine and amantadine dose-relatedly increased the cortical β<SUB>2</SUB> band in PIR, and these increasing effects, except in the case of physostigmine, were antagonized by the pretreatment of haloperidol. These results suggest that PIR is positioned as an animal model with the moderately lowered consciousness level intensively corresponding to semi coma in patients, and the dopaminergic system plays an important role rather than the cholinergic system in PIR.
- 公益社団法人 日本薬理学会の論文
著者
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Miura Yoshiki
Department Of Protein Biochemistry Institute Of Life Science Kurume University
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KADOKAWA Toshiaki
Department of Pharmacology, Research Laboratories, Dainippon Pharmaceutical Co. Ltd.
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ITO Tsugutaka
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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ITO Tsugutaka
Department of Pharmacology, Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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