Method for Estimation of Toxic Endotoxin in Inactivated Salmonella Vaccine in D-Galactosamine-Sensitized Mice

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概要

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• We developed a method to estimate the content of the toxic endotoxin in inactivated Salmonella vaccine in D-galactosamine-sensitized mice. Ten-fold serially diluted vaccines were injected intraperitoneally into D-galactosamine-sensitized mice. Lethality in the mice was judged 3 days after the injection. The best result was obtained when C3H/HeN mice were used for the test. Correlation was observed between the endotoxin content measured by Limulus amoebocyte lysate assay and the LD50 in the mouse safety test (r=0.81). These results suggested that this test could be applied to the estimation of endotoxin content in inactivated vaccines of Salmonella.

• 公益社団法人 日本獣医学会の論文

著者

• SAWATA Akira

  Research Center for Biologicals, The Kitasato Institute

• KUME Katsumi

  Research Center for Biologicals, The Kitasato Institute

• KAWAHARA Kazuyoshi

  Research Center for Biologicals, The Kitasato Institute

• TAKIKAWA Noriyasu

  Research Center for Veterinary Science, The Kitasato Institute

• TAKIKAWA Noriyasu

  Research Center for Biologicals, The Kitasato Institute

関連論文

• A Comparison of the Antibody Responses between Specific Pathogen-Free and Commercial Layers Immunized with an Influenza Vaccine Prepared from Inactivated Non-Pathogenic H5N1 Virus by Single Shot
• Histopathological, Immunopathological and Electron Microscopic Studies on Pig Liver Inoculated with Pasteurella multocida Dermonecrotic Toxin
• Early Serodiagnosis of Porcine Reproductive and Respiratory Syndrome Virus Infection of Pigs by Detection of Slow-Reacting and Complement-Requiring Neutralizing Antibodi.
• Method for Estimation of Toxic Endotoxin in Inactivated Salmonella Vaccine in D-Galactosamine-Sensitized Mice

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