Lesions of the Central Nervous System Induced by Intracerebral Inoculation of BALB/c Mice with Rabies Virus (CVS-11)
スポンサーリンク
概要
- 論文の詳細を見る
BALB/c mice were inoculated intracerebrally with fixed rabies virus (CVS-11) and pathomorphological changes in the central nervous system were studied. Infected mice showed ruffled hair, hunchback, anorexia, emaciation and ataxia at 5 days postinoculation (DPI), but paralysis did not occur. Viral antigens were first detected in the pyramidal cells of the cerebral cortex and hippocampus at 3 DPI, and these cells exhibited apoptosis at 5 DPI. Microglial cells and astroglial cells significantly increased in the areas of the nerve cells which showed apoptosis. However, spinal neurons and spinal dorsal root ganglion cells did not exhibit apoptosis despite virus infection. These observations indicate that different mechanism which causes apoptosis exists among the neurons of the brain and spinal cord, and glial cells play an important role in pathogenesis of the experimental rabies.
著者
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Chun-ho Park
Department Of Veterinary Pathology Faculty Of Veterinary Medicine And Animal Sciences Kitasato Unive
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Park Chun-ho
Department Of Comparative Pathology Graduate School Of Veterinary Medicine Hokkaido University
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Inoue Satoshi
Department Of Geriatric Medicine The University Of Tokyo
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Oyamada Toshifumi
Department Of Veterinary Pathology Faculty Of Veterinary Medicine And Animal Sciences Kitasato Unive
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Noguchi Akira
Department Of Agricultural And Biological Chemistry College Of Bioresource Sciences Nihon University
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KOJIMA Daisuke
Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University
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TSUJIKAWA Shintarou
Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University
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KOHARA Keiko
Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University
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HATAI Hitoshi
Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University
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Kojima Daisuke
Department Of Biophysics And Biochemistry Graduate School Of Science The University Of Tokyo
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Inoue Satoshi
Department Of Chemistry And Materials Engineering Faculty Of Chemistry Materials And Bioengineering
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Park Chun‐ho
Kitasato Univ. Aomori
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OYAMAD Toshifumi
Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University
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Inoue Satoshi
Department of Applied Chemistry, Graduate School of Engineering, Osaka University
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