Enhanced Release of Prostaglandin D_2 during Re-incubation of RAW 264.7 Macrophage-Like Cells after Treatment of Both Lipopolysaccharide and Non-steroidal Anti-inflammatory Drugs(Biochemistry/Molecular Biology)
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概要
- 論文の詳細を見る
RAW 264.7 macrophage-like cells are known to release prostaglandins (PCs), mainly PGD_2 to the culture medium after lipopolysaccharide (LPS)-treatment. This release was inhibited by non-steroidal anti-inflammatory drugs (NSAIDs), which are known to inhibit prostaglandin H_2 synthase (PGHS) activity. In this study, we examined the effect of removal of NSAID after induction of PGHS with LPS, on the release of PCs, which has not been studied well. Re-incubation of RAW 264.7 cells after treatment of both LPS and NSAIDs resulted in enhanced release of PGD_2 compared with the cells pretreated with LPS alone. Besides, PGHS activity was detectable in these cell homogenates and the amount of PGHS-2 protein showed similar changes to PGD_2 release. However, addition of NSAIDs again in the re-incubation period almost completely inhibited the PGD_2 release but increased the amount of PGHS-2 protein to the higher levels. Various types of NSAIDs used in this study showed similar effects on the changes in PGD_2 release and PGHS-2 protein amounts, except those on PGHS activity in cell homogenates; while indomethacin, aspirin, and NS-398 inhibited it, but nimesulide and acetaminophen did not. These results seem to suggest an importance for the caution that the enhanced induction of PGHS-2 protein and the concomitant release of PGs release would occur after removal of the NSAID not only from the medium in in vitro experiments but also from therapeutic prescription.
- 公益社団法人日本薬学会の論文
- 2004-07-01
著者
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IGIMI Shizunobu
Division of Biomedical Food Research, National Institute of Health Sciences
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Tanaka Yasuhito
Department Of Orthopaedic Surgery Nara Medical University
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TAKIZAWA Makiko
Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto Univers
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Amano F
Department Of Hygienic Chemistry Osaka University Of Pharmaceutical Sciences
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Amano Fumio
Department Of Biochemistry And Cell Biology National Institute Of Infectious Diseases
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Igimi Shizunobu
Division Of Biomedical Food Research National Institute Of Health Sciences
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Igimi S
Division Of Biomedical Food Research National Institute Of Health Sciences
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Igimi Shizunobu
Division Of Biomedical Food Research National Institute Of Health Sciences;
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Tanaka Yasuhito
Department Of Internal Medicine Aiseikai Yamashina Hospital
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Amano Fumio
Department Of Biochemistry And Cell Biology National Institute Of Infectious Disease
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Amano Fumio
Department Of Biochemistry And Cell Biology National Institute Of Health
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Tanaka Yasuhito
Department Of Biochemistry And Cell Biology National Institute Of Health
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Takizawa Makiko
Department Of Biochemistry And Cell Biology National Institute Of Infectious Diseases
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Tanaka Yasuhito
Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases
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