An Anti-Salmonella Antibody Prevents the Salmonella enterica serovar Enteritidis from Infecting the Human Intestinal Epithelial Cell Line, Caco-2, by Interacting with Flagella

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概要

• 論文の詳細を見る

• A polyclonal antibody of Salmonella enterica serovar Enteritidis (SE), designated RY542, inhibited SE from attaching to and invading the human intestinal epithelial cell line, Caco-2, in a dose-dependent manner. A major immunoreactive band of 55 kDa obtained in western blotting using RY542 was identified as FliC. An affinity-purified anti-flagellin antibody from RY542 similarly inhibited the infection. These results suggest that RY542 is a neutralizing antibody that blocks the infection of SE in Caco-2 cells by interacting with flagella, and that flagellin may potentially be useful as a component of a Salmonella vaccine.

• 日本ビフィズス菌センターの論文
• 2006-07-01

著者

• IGIMI Shizunobu

  Division of Biomedical Food Research, National Institute of Health Sciences

• AMANO Fumio

  Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences

• Amano Fumio

  Laboratory Of Biodefense & Regulation Osaka University Of Pharmaceutical Sciences

• Amano Fumio

  Lab. Of Biodefense & Regulation Osaka Univ. Of Pharmaceutical Sciences Jpn

• Igimi Shizunobu

  Division Of Biomedical Food Research National Institute Of Health Sciences

• Igimi S

  Division Of Biomedical Food Research National Institute Of Health Sciences

• Igimi Shizunobu

  Division Of Biomedical Food Research National Institute Of Health Sciences;

• YAMAMOTO SHIGEKI

  Division of Cardiovascular Surgery, Nagoya City University Medical School

• YAMASAKI MANABU

  Division of Biomedical Food Research, National Institute of Health Sciences

• KAJIKAWA Akinobu

  Division of Biomedical Food Research, National Institute of Health Sciences

• Kajikawa Akinobu

  Division Of Biomedical Food Research National Institute Of Health Sciences

• Yamasaki Manabu

  Division Of Biomedical Food Research National Institute Of Health Sciences

• Amano F

  Laboratory Of Biodefense & Regulation Osaka University Of Pharmaceutical Sciences

• Yamamoto Shigeki

  Division Of Biomedical Food Research National Institute Of Health Sciences

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