Circadian Variation of Autonomic Nervous Activity in Patients With Multivessel Coronary Spasm
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概要
- 論文の詳細を見る
The present study investigated whether the circadian rhythm of sympathovagal activity is related to the severity of coronary spasm or multivessel coronary spasm. Heart rate variability was examined in 22 consecutive patients with vasospastic angina provoked by intracoronary injection of acetylcholine, who had either multivessel spasm (Group M, n=11) or single vessel spasm (Group S, n=11), in 20 subjects without coronary artery disease (Group C) and 20 patients with effort angina who had organic coronary artery stenosis (Group E). The frequency domain indices were analyzed, including low frequency (LF:0.04-0.15Hz) and high frequency (HF:0.15-0.4Hz), the latter being an index of efferent parasympathetic activity, and the ratio (L/H) as an index of sympathovagal balance. The circadian variation of the parameters was analyzed by its pattern and was quantified by the difference of the mean values between daytime and nighttime. Although the HF power increased during nighttime in Groups C and S, this increase was attenuated in Groups E and M. The circadian variation of the L/H ratio (ie, a drop during nighttime) was smaller in the S and M groups than in Groups C and E. Accordingly, in Group M, the circadian variation of both sympathetic and parasympathetic nervous activity was attenuated, but in Group S, the variation of sympathetic nervous activity, but not parasympathetic nervous activity, was decreased. These data suggest that relatively enhanced sympathetic nervous activity at night may be involved in the mechanism underlying multivessel coronary spasm.
- 社団法人日本循環器学会の論文
- 2001-06-20
著者
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WATANABE Tsuyoshi
Fukushima Medical University
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OUCHI Yasuyoshi
Department of Geriatric Medicine, University of Tokyo
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SHIMADA Kazuyuki
Department of Medicine, Jichi Medical University
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AKISHITA Masahiro
Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
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KARIO Kazuomi
Department of Cardiology, Jichi Medical University
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Akishita Masahiro
Department Of Geriatric Medicine Graduate School Of Medicine The University Of Tokyo
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WATANABE Tokumitsu
Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
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KIM Seungbum
Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
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Mitsuhashi Takeshi
Department Of Cardiovascular Medicine Shinshu University Graduate School Of Medicine
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Kim Seungbum
Department Of Geriatric Medicine Graduate School Of Medicine University Of Tokyo
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SEKIGUCHI Hiromichi
Department of Cardiology, Jichi Medicical School
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FUJIKAWA Hideyuki
Department of Cardiology, Jichi Medicical School
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Fujikawa Hideyuki
Utsunomiya Social Insurance Hospital
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Ouchi Yasuyoshi
Department Of Geriatric Medicine Faculty Of Medicine The University Of Tokyo
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Mitsuhashi Takeshi
Department Of Cardiology Jichi Medical School
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Kario Kazuomi
Department Of Cardiology Jichi Medical School
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Shimada Kazuyuki
Department Of Anatomy School Of Medicine Showa University
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Wada Takashi
Department Of Laboratory Medicine Institute Of Medical Pharmaceutical And Health Sciences Faculty Of
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Sekiguchi Hiromichi
Department Of Cardiology Jichi Medical School
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Fujikawa Hideyuki
The Department Of Cardiology Jichi Medical School
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Fujikawa Hideyuki
Department Of Cardiology Jichi Medical School
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Ouchi Yasuyoshi
Department Of Biostatistics Epidemiology And Preventive Health Sciences University Of Tokyo
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Ouchi Yasuyoshi
Department Of Biostatistics Epidemiology And Preventive Health Sciences The University Of Tokyo
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Watanabe Tokumitsu
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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