Involvement of Renal γ-Glutamyltranspeptidase in Differences in the Renal Uptake of Mercuric Mercury by Male and Female Mice of Various Strains and Ages
スポンサーリンク
概要
- 論文の詳細を見る
Involvement of renal γ-glutamyltranspeptidase (γ-GTP) in differences in the renal uptake of Hg^<2+> by male and female mice of various ages was examined using five strains of mice, namely, BALB/cA, C57BL/6N, CBA/JN, C3H/HeN and ICR. We observed strain-related and gender-related differences in the renal accumulation of Hg<2+> 30min after the administration of mercuric chloride (1μmol/kg, s.c.). Renal γ-GTP activity also varied among the tested strains, and the activity in males was about twice that in females. A significant correlation was recognized between renal γ-GTP activity and the renal accumulation of Hg<2+>. Both renal uptake of Hg<2+> and renal γ-GTP activity increased gradually with age in male ICR mice from 2 to 8 weeks after birth but remained relatively constant in ICR females. Significant gender-related differences in both renal accumulation of Hg<2+> and γ-GTP activity were observed 4 weeks after birth and thereafter. Castration of male ICR mice decreased both renal accumulation of Hg<2+> and γ-GTP activity to the levels in females. Injection of testosterone increased both renal accumulation of Hg<2+> and γ-GTP activity in castrated male mice and in normal female mice to the levels in control male mice. These results suggest that strain-related, gender-related and age-related differences in the renal accumulation of Hg<2+> in mice might be due to differences in renal γ-GTP activity and, furthermore, that renal γ-GTP activity might be controlled, at least to some extent, by testosterone.
- 公益社団法人日本薬学会の論文
- 1999-04-30
著者
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Imura Nobumasa
Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato Un
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Imura Nobumasa
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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NAGANUMA Akira
Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato Un
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Naganuma Akira
Department Of Molecular And Biochemical Toxicology Faculty Of Pharmaceutical Sciences Tohoku Univers
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KOBAYASHI Kazuo
Department of Materials Science and Engineering, Faculty of Engineering, Nagasaki University
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Miura Nobuhiko
Department Of Molecular And Biochemical Toxicology Faculty Of Pharmaceutical Sciences Tohoku Univers
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Tanaka-kagawa Toshiko
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Naganuma Akira
Department Of Molecular And Biochemical Toxicology Faculty Of Pharmaceutical Sciences Tohoku Univers
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Imura Nobumasa
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Kobayashi Kazuo
Department Of Civil Engineering At The Osaka Institute Of Technology
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Kobayashi Kazuo
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Kobayashi Kazuo
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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