Novel Bioassey for the Assessment of Neurotoxicity of Chemicals Based on the Neurite Extension in Human Neuroblastoma NB-1 Cells
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概要
- 論文の詳細を見る
A new testing method for the assessment of hazardous environmental chemicals using cultured human neuronal cells has been developed. This method is based on the image analysis of the neurite extension in human neuroblastoma NB-1 cells : the length of the extended neurites was determined using image analysis software. Using this system, 255 chemicals including methylmercury and endocrine disrupting chemicals were tested. Methylmercury and several chemicals inhibited neurite extension, while cadmium chloride, phthalates, and many other chemicals promoted it. These results suggest that the extended neurite length is a useful biological marker for the effects of neurotoxic environmental chemicals, especially on the developing nervous system.
- 社団法人日本薬学会の論文
- 2003-08-01
著者
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SAKAUE Motoharu
Department of Anatomy II School of Veterinary Medicine, Azabu University
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Hara Shuntaro
Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato Un
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Hara Shuntaro
北里大学 薬学部公衆衛生学教室
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Hara S
Department Of Public Health School Of Pharmaceutical Sciences Kitasato University
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Hara Shuntaro
Department Of Health Chemistry School Of Pharmaceutical Sciences Showa University
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Kunimoto Manabu
Department of Public Health, School of Pharmaceutical Sciences, Kitasato University
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Yoshimi Risa
Department of Public Health, School of Pharmaceutical Sciences, Kitasato University
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Matsushita Sachiko
Department of Public Health, School of Pharmaceutical Sciences, Kitasato University
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Takanaga Hiromi
Department of Public Health, School of Pharmaceutical Sciences, Kitasato University
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Utsumi Hideo
Laboratory of Bio-function Analysis, Graduate School of Pharmaceutical Sciences, Kyushu University
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Nakasugi Osami
Chemical Risk Assessment Center, National Institute for Environmental Studies
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Yoshimi Risa
Department Of Public Health School Of Pharmaceutical Sciences Kitasato University
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Nakasugi Osami
Chemical Risk Assessment Center National Institute For Environmental Studies
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Sakaue M
Kitasato Univ. Tokyo
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Sakaue Motoharu
Department Of Anatomy Ii School Of Veterinary Medicine Azabu University
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Kunimoto Manabu
Department Of Public Health School Of Pharmaceutical Sciences Kitasato University
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Takanaga Hiromi
Department Of Public Health School Of Pharmaceutical Sciences Kitasato University
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Matsushita Sachiko
Department Of Public Health School Of Pharmaceutical Sciences Kitasato University
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Matsushita Sachiko
Department Of Applied Chemistry Graduate School Of Engineering The University Of Tokyo
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Utsumi Hideo
Laboratory Of Bio-function Analysis Graduate School Of Pharmaceutical Sciences Kyushu University
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Sakaue M
Department Of Public Health School Of Pharmaceutical Sciences Kitasato University
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