Maternal Exposure to Low Doses of DES altered mRNA Expression of Hepatic Microsomal Enzymes in Male Rat Offspring
スポンサーリンク
概要
- 論文の詳細を見る
Our previous studies demonstrated that prenatal diethylstilbestrol (DES) treatment disrupts steroidogenesis but induces high-level expression of androgen receptor (AR) mRNA to inhibit the disruption of spermatogenesis. This study examined which prenatal DES treatment influenced hepatic microsomal enzymes, CYP3A1, CYP2B1/2, CYP2C11, UGT2B1 (UDP-glucuronosyltransferase 2B1), and IGF-1 (insulin-like growth factor-1), in male offspring. DES treatment decreased the mRNA expression levels of CYP3A1 and CYP2B1/2, but did not alter the expression of CYP2C11. At 6 weeks, DES treatment increasd the mRNA expression levels of UGT2B1 and IGF-1. These results suggest that prenatal DES treatment alters two hepatic enzymes (CYP3A1 and CYP2B1/2) and IGF-1 mRNA expression levels to counteract the low level of testosterone, but this disrupted UGT2B1 mRNA expression reduces the testosterone level.
著者
-
Sakaue Motoharu
Department Of Anatomy Ii School Of Veterinary Medicine Azabu University
-
Shirai Mitsuyuki
Department Of Veterinary Pharmacology School Of Veterinary Medicine Azabu University
-
Arishima Kazuyoshi
Department Of Anatomy Ii School Of Veterinary Medicine Azabu University
-
Arishima Kazuyoshi
Department Of Veterinary Anatomy Ii Azabu University School Of Veterinary Medicine
-
Arishima Kazuyoshi
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
-
Yamamoto Masako
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
-
Kobayashi Tetsuo
Department Of Anatomy Ii School Of Veterinary Medicine Azabu University
-
Murakami Masaru
Department Of Cardiology Tokushima Prefectural Central Hospital
-
Nishikawa Osamu
Department Of Earth Sciences Faculty Of Science Kanazawa University
-
ARISHIMA Kazuyoshi
Department of Anatomy II
-
SHIRAI Mitsuyuki
Department of Pharmacology, Azabu University School of Veterinary Medicine
-
KOBAYASHI Tetsuo
Department of Anatomy II
-
NISHIKAWA Osamu
Department of Anatomy II, School of Veterinary Medicine, Azabu University
-
ARISHIMA Kazuyoshi
Department of Anatomy II, School of Veterinary Medicine, Azabu University
関連論文
- EFFECTS OF MATERNAL EXPOSURE TO A LOW DOSE OF DIETHYLSTILBESTROL ON SEXUAL DIMORPHIC NUCLEUS VOLUME AND MALE REPRODUCTIVE SYSTEM IN RAT OFFSPRING
- An Up-to-Date Anti-Cancer Treatment Strategy Focusing on HIF-1α Suppression : Its Application for Refractory Ovarian Cancer
- Effects of Maternal Exposure to Low Doses of DES on Testicular Steroidogenesis and Spermatogenesis in Male Rat Offspring
- Malignant transformation of atypical endometrial hyperplasia after progesterone therapy showing germ-cell tumor-like differentiation
- Immunohistochemical Expression of Type-1 Carbohydrate Antigens : Availability of DU-PAN-2 on Pathological and Clinical Aspects
- Novel Bioassey for the Assessment of Neurotoxicity of Chemicals Based on the Neurite Extension in Human Neuroblastoma NB-1 Cells
- Heat Stress as a Countermeasure for Prevention of Muscle Atrophy in Microgravity Environment
- Uterine body cancer mass screening at Tokai University Hospital
- Serum carbohydrate antigen elevations in endometrial adenocarcinomas : Characterization of DU-PAN-2 expression as a tumor marker
- Modification of p53 Immunoexpression Associated with Chemotherapy Regimens in Advanced and Refractory Ovarian Cancers(Prof. K Watanabe Memorial Article)
- IS-6 Induction of specific cytotoxic T-lymphocyte (CTL) responses in patients with cervical cancer using an human papillomavirus (HPV)-16 E7 peptide and autologous dendritic cells
- Clinicopathological Analysis of DU-PAN-2 as a Tumor Marker for Endometrial Adenocarcinoma in Comparison with CA19-9
- Long-term results and prognostic analysis in advanced and recurrent / refractory epithelial ovarian cancer treated by high-dose cyclophosphamide, adriamycin, and cisplatin with autologous bone marrow transplantation
- 成熟雄ラットへのビンクロゾリン投与による精子形成およびテストステロン生合成経路への影響
- Chymase is Activated in the Pulmonary Inflammation and Fibrosis Induced by Paraquat in Hamsters
- Ovarian carcinomas with neuroendocrine differentiation : Review of five cases referring to immunohistochemical characterization
- Gelatinolytic localization of gynecologic tumors Applying in situ zymography
- Follow-up Laparoscopy in Patients with Ovarian Cancer
- Improvement of a Pulse Generator for the Atom-Probe: Doubling of Pulse-Voltage
- Treatment Strategy for Recurrent and Refractory Epithelial Ovarian Cancer : Efficacy of High-Dose Chemotherapy with Hematopoietic Stem Cell Transplantation
- II-C-14 Association of GLUT-1 expression in ovarian neoplasms with the tumor grade(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- DILATING EFFECT OF PROSTAGLANDIN ON THE CONSTRICTED DUCTUS ARTERIOSUS IN NEWBORN RATS
- A CALCIUM CHANNEL BLOCKER VERAPAMIL INHIBITS THE SPONTANEOUS CLOSURE OF THE DUCTUS ARTERIOSUS IN NEWBORN RATS
- Transplacentally-Administered Enalapril Inhibits the Spontaneous Constriction of the Ductus Arteriosus in the Newborn Rat
- High-normal Creatinine on Presentation Predicts Left Ventricular Dysfunction after Successful Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 5 (IHD), The 69th Ann
- Short-Interfering RNA-Mediated Silencing of Thioredoxin Reductase 1 Alters the Sensitivity of HeLa Cells toward Cadmium(Molecular and Cell Biology)
- OJ-026 ST-segment Resolution Predicts Left Ventricular Function in Chronic State after Primary Percutaneous Intervention for Acute ST-segment Elevation Myocardial Infarction.(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 1 (IHD) : OJ4)(Oral
- Study of Field Emission Characteristics of Carbon with the Scanning Atom Probe
- Expression Profile of Amylolytic Genes in Aspergillus nidulans
- The Region in a Subunit of the Aspergillus CCAAT-Binding Protein Similar to the HAP4p-Recruiting Domain of Saccharomyces cerevisiae Hap5p Is Not Essential for Transcriptional Enhancement
- Mode of AmyR Binding to the CGGN_8AGG Sequence in the Aspergillus oryzae taaG2 Promoter
- No Factors Except for the Hap Complex increase the Taka-amylase A Gene Expression by Binding to the CCAAT Sequence in the Promoter Region(Biochemistry & Molecular Biology)
- In Vivo and in Vitro Analyses of the AmyR Binding Site of the Aspergillus nidulans agdA Promoter ; Requirement of the CGG Direct Repeat for Induction and High Affinity Binding of AmyR(Biochemistry & Molecular Biology)
- A Simple and Rapid Method for the Preparation of a Cell-free Extract with CCAAT-Binding Activity from Filamentous Fungi
- The Herbal Medicine Tokishakuyakusan Increases Fetal Blood Glucose Concentrations and Growth Hormone Levels and Improves Intrauterine Growth Retardation Induced by N^ω-Nitro-L-arginine Methyl Ester
- Prenatal Exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126) Promotes Anxiogenic Behavior in Rats
- Scanning Tunneling and Atomic Force Microscopy of T4 Bacteriophage and Tobacco Mosaic Virus
- HISTOMETRIC CHANGES IN CONNECTIVE FIBERS OF THE LUNG FOLLOWING PARAQUAT ADMINISTRATION IN RATS
- HISTOMETRIC CHANGES IN CONNECTIVE FIBERS OF THE LUNG FOLLOWING PARAQUAT ADMINISTRATION IN RATS
- Morphometric Study on the Fetal Thyroid Gland in the Nude Mouse (BALB/cAnNCrj-nu/nu)
- "P-11 Constrictive Effects of indomethacin, Paraquat and Diquat on the Ductus Arteriosus in Fetal Rats.
- CONSTRICTIVE EFFECTS OF PARAQUAT ON THE DUCTUS ARTERIOSUS IN FETAL RATS
- CONSTRICTIVE EFFECTS OF PARAQUAT ON THE DUCTUS ARTERIOSUS IN FETAL RATS
- 平成13年度助成研究・援助金報告 Eruptive History of Tangkuban Perahu Volcano, West Java, Indonesia: A Preliminary Report
- BIPYRIDYLIUM HERBICIDE AND DUCTUS ARTERIOSUS II
- BIPYRIDYLIUM HERBICIDE AND DUCTUS ARTERIOSUS I
- 2A-10 EFFECTS OF P=S TYPE ORGANOPHOSPHORUS INSECTICIDES ON THE FETAL DUCTUS ARTERIOSUS IN THE RAT
- INHIBITORY EFFECT OF INDOMETHACIN ON NEONATAL LUNG CATABOLISM OF PROSTAGLANDIN E_2: POSSIBLE MECHANISM OF THE RE-OPENING OF THE DUCTUS ARTERIOSUS AFTER INDOMETHACIN THERAPY
- QUANTIFIABLE MORPHOLOGIC EVALUATION OF PARAQUAT PULMONARY TOXICITY IN RATS
- Regulatory Mechanisms of Reproductive Effort in Plants : III. Plasticity in Reproductive Energy Allocation and Propagule Output of Two Grass Species, Oryza sativa cv. Akihikari and Coix ma-yuen Cultivated at Varying Densities and Nitrogen Levels, and the
- AMS Radiocarbon Dating of Paleosols Intercalated with Tephra Layers from Mayon Volcano, Southern Luzon, Philippines : A Preliminary Report
- Effect of Dietary Green Tea Catechin Preparation on Oxidative Stress Parameters in Large Intestinal Mucosa of Rats
- Therapeutic strategy targeting the mTOR-HIF-1α-VEGF pathway in ovarian clear cell adenocarcinoma
- Developmental toxicity of indium : Embryotoxicity and teratogenicity in experimental animals
- An Assessment of Mutagenic Effect of 3, 3, 4, 4, 5 Pentachlorobiphenyl (PCB126) in Muta Mouse Fetuses
- P10-04 Changes Detected in Plasma Antiproteases in Paraquat Poisoned Rats Using Micro Two-Dimensional Electrophoretic Analysis
- Functional morphology of the forelimb muscles in an aardvark
- ホッキョクグマ(Ursus maritimus),ヒグマ(Ursus arctos)およびジャイアントパンダ(Ailuropoda melanoleuca)の橈側種子骨に関する比較解剖学的検討
- Effects of Maternal Exposure to Diethylstilbestrol on Epididymal Development in Rat Offspring(Anatomy)
- EFFECTS OF MATERNAL EXPOSURE TO DIETHYLSTILBESTROL ON THE DEVELOPMENT OF THE REPRODUCTIVE SYSTEM AND THYROID FUNCTION IN MALE AND FEMALE RAT OFFSPRING
- Anatomy and histology of the stomach in a newborn pygmy hippopotamus (Choeropsis liberiensis)
- The superficial layer of the Musculus masseter and the well-developed process of the maxilla in the tiger Panthera tigris
- Lack of Constrictive Effects of Cocaine on the Fetal Ductus Arteriosus in the Rat
- Resolution of Cu Atoms in a GP[1] Zone in Al-Cu by FIM and Determination of the GP[1] Structure
- Field Emission Microscope Images of Oxygen Adsorption on Tungsten at 300 K and at Higher Coverages
- Isolation and Characterization of the IS3-like Element from Thermus aquaticus
- Inducer-Dependent Nuclear Localization of a Zn(II)_2Cys_6 Transcriptional Activator, AmyR, in Aspergillus nidulans
- Hypoxia-Inducible Factor-3α Functions as an Accelerator of 3T3-L1 Adipose Differentiation
- A Child with Adrenocortical Adenoma Accompanied by Congenital Hemihypertrophy : Report of a Case
- Novel Promoter Sequence Required for Inductive Expression of the Aspergillus nidulans Endoglucanase Gene eglA
- Cell Count Value of Pituitary Basophils and Serum TSH, LH and FSH Concentrations During the Short Interval after Thyroidectomy
- APPLICATION OF IMMUNOCYTOCHEMISTRY TO THE CYTOLOGIC STUDY OF PERITONEAL FLUIDS IN PATIENTS WITH OVARIAN CANCER
- Assessment of Potential Neurotoxic Actions of Organoarsenic Compounds Using Human Neuroblastoma NB-1 Cells and Rat Cerebellar Neurons in Primary Culture
- Maternal Exposure to Low Doses of DES altered mRNA Expression of Hepatic Microsomal Enzymes in Male Rat Offspring
- An Airlock for a Resistively Heatable Specimen of a Field Ion Microscope and an Atom-Probe
- Xylose Triggers Reversible Phosphorylation of XlnR, the Fungal Transcriptional Activator of Xylanolytic and Cellulolytic Genes in aspergillus oryzae
- Failure of Estradiol Benzoate Given after Birth to Prevent the Adrenal Glands from Shrinking in Newborn Rats
- Chemical and microbiological investigations of hot spring deposits found at the hydrothermal systems of Kamchatka Peninsula, Russia
- Depressed Oxidative Function in Gingival Crevicular Polymorphonuclear Leukocytes from Porphyromonas gingivalis-detectable Periodontal Pockets
- Immunohistochemical Localization and Gene Expression of Carbonic Anhydrase Isoenzymes CA-II and CA-VI in Canine Lower Airways and Lung
- Acquisition Parameters for Diffusion Tensor Imaging to Emphasize Fractional Anisotropy : Phantom Study
- Long Term Prognostic Implications of Expression of Glucose Transporter-1 and Hexokinase II in Patients with Stage I Uterine Leiomyosarcoma
- Plasma Profiles of Glucose, Insulin and Lipids in the Male WBN/Kob-Leprfa Rat, a New Model of Type 2 Diabetes with Obesity
- Comprehensive Analysis of the DNA-Binding Specificity of an Aspergillus nidulans Transcription Factor, AmyR, Using a Bead Display System
- Diversity of Fimbrillin among Porphyromonas gulae Clinical Isolates from Japanese Dogs
- Culture on a Fragmin/Protamine-Coated Plate Suppresses the Collagen Type IαI and TGF-β1 mRNA Expression of Rat Hepatic Stellate RI-T Cells
- Preliminary Results of Pollen Analysis and Its Implications to Paleoenvironment in Paitan Lake, Nueva Ecija, Philippines
- Stratigraphy of Cored Sediments from North of the Irosin Caldera, Sorsogon, Philippines
- Granulosa cell tumor with activated mTOR-HIF-1α-VEGF pathway
- RESULTS AND EFFECTIVENESS OF THYMECTOMY VIA THE SUPRASTERNAL NOTCH IN MYASTHENIA GRAVIS
- Correlation of Age with Distribution of Periodontitis-Related Bacteria in Japanese Dogs
- Immunohistolocalization and Gene Expression of Secretory Carbonic Anhydrase Isoenzyme CA-VI in Canine Nasal Cavity
- Hydrodynamic characterization of amylose-SDS complex by viscosity measurement.
- Interaction of amylose with iodine. I. Characterization of cooperative binding isotherms for amyloses.
- Kinetic studies of the complex formation in the system of cyclodextrin, iodine, and iodide.
- Cooperativity in the binding of sodium dodecyl sulfate to amylose.
- SURGICAL TREATMENT OF TRACHEAL LESIONS
- Smooth Muscle Cell Proliferation in the Ductus Arteriosus and the Descending Aorta, and Effects of Enalapril on SMC Proliferation in Perinatal Rats.
- RNA tumor virus-like particles in thymus cells of patients with myasthenia gravis.
- Structural Elucidation of Alterporriol B, a Novel Metabolic Pigment Produced by Alternaria porri (Ellis) Ciferri