Clinicopathological Analysis of DU-PAN-2 as a Tumor Marker for Endometrial Adenocarcinoma in Comparison with CA19-9
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概要
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We investigated the clinical and immunohistochemical availability of DU-PAN-2 (sialyl Lewis^c) as a tumor marker for endometrial adenocarcinomas (EMACs) in comparison with that of CA19-9 (sialyl Lewis^a). Serum DU-PAN-2 and CA19-9 values of 17 EMACs were measured using an EIA kit and a RIA kit, respectively. The positive/negative cutoff values for both markers were set at the [mean+2xSD] from the serum values of 19 benign uterine cases as follows; DUPAN-2, 73.9 U/mL; CA19-9, 37.4 U/mL. Immunohistochemical expressions of DU-PAN-2 and CA19-9 in EMACs were analyzed, applying an indirect immunoperoxidase method. The Lewis blood group type was determined using the hemagglutination test. The serum elevations of DU-PAN-2 and CA19-9 higher than the cutoff values before surgery were noted in 29.4% (5/17) and 23.5% (4/17) of EMACs, respectively. Except for one patient who died of systemic tumor dissemination, the elevated serum values of DU-PAN-2 and CA19-9 declined to the levels lower than the cutoff values after surgery. The relationship between immunohistochemical profiles and serum values was statistically proven to be closer in DU-PAN-2 (r=0.609, p=0.0094) than in CA19-9 (r=0.326, p=0.2022). The Lewis negative patients among them were consistently negative for CA19-9 serologically. We believe that DU-PAN-2 could be clinically useful in EMACs as well as immunohistochemically and recommend that this be added into a panel of tumor markers for EMACs.
- 日本組織細胞化学会の論文
著者
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OSAMURA R.
Department of Pathology, Tokai University School of Medicine
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Yasuda Masanori
Department of Pathology, Saitama Medical University International Medical Center
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Murakami Masaru
Department of Obstetrics and Gynecology, Tokai University School of Medicine
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Kajiwara Hiroshi
Department of Pathology, Tokai University School of Medicine
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Muramatsu Toshinari
Department of Obstetrics and Gynecology, Tokai University School of Medicine
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Osamura R.yoshiyuki
東海大学 医学研究科病理病態学
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Makino Tsunehisa
Departments Of Obstetrics And Gynecology Tokai University
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Makino Tsunehisa
東海大学 医学部産婦人科学
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Osamura Yoshiyuki
東海大学 医学研究科病理病態学
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Osamura R.yoshiyuki
東海大学 医学部病理診断学
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Osamura R
東海大学 医学研究科病理病態学
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Osamura R.yoshiyuki
東海大学教育･研究支援センター
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Osamura R.
Department Of Pathology School Of Medicine Tokai University
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Kamoshida Shingo
Department of Pathology, Fujita Health University School of Medicine
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Yamauchi Itaru
Division of Obstetrics and Gynecology, Isehara Kyodo Hospital
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Kajiwara Hiroshi
Division of and Pathology, Isehara Kyodo Hospital
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Makino Tunehisa
Departments of Obstetrics and Gynecology, Tokai University School of Medicine
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Yasuda M
Department Of Pathology Tokai University School Of Medicine
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Yasuda Masanori
Department Of Pathology School Of Medicine Tokai University
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Muramatsu Toshinari
Department Of Obstetrics And Gynecology School Of Medicine Tokai University
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Yasuda Masanori
Departments Of Pathology Tokai University School Of Medicine
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Miyazawa Masaki
Department Of Pathology Tokai University School Of Medicine
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Miyazawa Masaki
Department Of Pathodiagnostics Course Of Basic Clinical Science Tokai University School Of Medicine
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Kamoshida Shingo
Department Of Pathology Fujita Health University School Of Medicine
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Kajiwara Hiroshi
Department Of Pathology Tokai University School Of Medicine
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Murakami Masashi
Department Of Biochemistry Cancer Institute Okayama University Medical School
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Kajiwara Hiroshi
Pharmacological Research Laboratories Drug Safety Testing Center Co. Ltd.
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Kajiwara Hiroshi
Department Pathology Of Tokai University School Of Medicine
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Kamoshida S
Department Of Pathology Fujita Health University School Of Medicine
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Yamauchi Itaru
Division Of Obstetrics And Gynecology Isehara Kyodo Hospital
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Murakami Masaru
Department Of Obstetrics And Gynecology Tokai University School Of Medicine
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Murakami Masaru
Department Of Molecular Biology School Of Veterinary Medicine Azabu University
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Miyazawa Masaki
Department Of Pathology School Of Medicine Tokai University
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Katakami Hideki
Departments Of Internal Medicine Miyazaki Medical College
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Osamura R.
Tokai Univ. School Of Medicine Kanagawa Jpn
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Kajiwara Hiroshi
Departments Of Pathology School Of Medicine Tokai University
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Yamazaki Michio
Department Of Pathology Saitama Medical University International Medical Center
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Katakami H
Department Of Pathology Tokai University School Of Medicine
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Miyazawa Masaki
Department Of Obstetrics And Gynecology Tokai University School Of Medicine
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Marugami Yoshihisa
Department Of Pathology Fujita Health University School Of Medicine
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Murakami Masaru
Department Of Cardiology Tokushima Prefectural Central Hospital
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Osamura R.yoshiyuki
Dept Of Pathology Tokai Univ School Of Medicine
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Yasuda Masanori
東海大学 医学部病理学
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Yasuda Masanori
Department Of Pathology Saitama Medical University International Medical Center
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Muramatsu T
Tokyo Dental Coll. Chiba
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Murakami Masaru
Department Of Pathodiagnostics Course Of Basic Clinical Science Tokai University School Of Medicine
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Yasuda Masanori
Department Of Neurosurgery Nippon Medical School
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